PDE6 alpha (PDE6A) (NM_000440) Human Recombinant Protein
CAT#: TP761211
Purified recombinant protein of Human phosphodiesterase 6A, cGMP-specific, rod, alpha (PDE6A), full length, with N-terminal HIS tag, expressed in E. coli, 50ug
Other products for "PDE6A"
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length PDE6A
|
Tag | N-His |
Predicted MW | 99.4 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 50mM Tris, 8M Urea, pH8.0. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_000431 |
Locus ID | 5145 |
UniProt ID | P16499 |
Cytogenetics | 5q32 |
Refseq Size | 5659 |
Refseq ORF | 2580 |
Synonyms | CGPR-A; PDEA; RP43 |
Summary | This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa. [provided by RefSeq, Jul 2008] |
Protein Families | Druggable Genome |
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