IL12RB1 (NM_153701) Human Recombinant Protein
CAT#: TP761820
Purified recombinant protein of Human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 2, full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding human full-length IL12RB1
|
Tag | N-GST and C-His |
Predicted MW | 67.6 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 50mM Tris, pH8.0,8M Urea. |
Storage | Store at -80°C. |
Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_714912 |
Locus ID | 3594 |
UniProt ID | P42701 |
Cytogenetics | 19p13.11 |
Refseq Size | 1881 |
Refseq ORF | 1143 |
Synonyms | CD212; IL-12R-BETA1; IL12RB; IMD30 |
Summary | 'The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]' |
Protein Families | Druggable Genome, Transmembrane |
Protein Pathways | Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway |
Documents
FAQs |
Resources
Recombinant Protein Resources |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
LC403516 | IL12RB1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 121.00 |
|
LC417240 | IL12RB1 HEK293T cell transient overexpression lysate (as WB positive control) |
USD 187.00 |
|
LY403516 | Transient overexpression lysate of interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 2 |
USD 396.00 |
|
LY417240 | Transient overexpression lysate of interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1 |
USD 605.00 |
|
PH321974 | IL12RB1 MS Standard C13 and N15-labeled recombinant protein (NP_005526) |
USD 2,055.00 |
|
TP321974 | Recombinant protein of human interleukin 12 receptor, beta 1 (IL12RB1), transcript variant 1 |
USD 788.00 |
{0} Product Review(s)
Be the first one to submit a review