Factor IX (F9) (NM_000133) Human Recombinant Protein

CAT#: TP761962

Purified recombinant protein of Human coagulation factor IX (F9),full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug


  View other "F9" proteins (3)

USD 215.00

In Stock*

Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding full-length of F9
Tag N-GST and C-His
Predicted MW 79.8 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol,1% Sarkosyl.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000124
Locus ID 2158
UniProt ID P00740
Cytogenetics Xq27.1
Refseq Size 2804
Refseq ORF 1383
Synonyms F9 p22; FIX; HEMB; P19; PTC; THPH8
Summary 'This gene encodes vitamin K-dependent coagulation factor IX that circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Sep 2015]'
Protein Families Druggable Genome, Protease, Secreted Protein
Protein Pathways Complement and coagulation cascades

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