p95 NBS1 (NBN) (NM_002485) Human Recombinant Protein

CAT#: TP762026

Purified recombinant protein of Human nibrin (NBN),Pro461-Arg754, with N-terminal His tag, expressed in E. coli, 50ug

Product Images

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region(Pro461-Arg754) of NBN
• Tag: N-His
• Predicted MW: 34 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, pH8.0, 150 mM NaCl, 10% glycerol,1% Sarkosyl.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_002476
• Locus ID: 4683
• UniProt ID: O60934
• Cytogenetics: 8q21.3
• Refseq Size: 4639
• Refseq ORF: 2262
• Synonyms: AT-V1; AT-V2; ATV; NBS; NBS1; P95
• Summary: 'Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation. [provided by RefSeq, Jul 2008]'
• Protein Families: Druggable Genome
• Protein Pathways: Homologous recombination