BNP (NPPB) (NM_002521) Human Recombinant Protein

CAT#: TP762128

Purified recombinant protein of Human natriuretic peptide B (NPPB), His27-Arg102, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein BNP was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region( His27-Arg102) of BNP
• Tag: N-His
• Predicted MW: 8.5 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_002512
• Locus ID: 4879
• UniProt ID: P16860
• Cytogenetics: 1p36.22
• Refseq Size: 708
• Refseq ORF: 402
• Synonyms: BNP
• Summary: 'This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The presence of myocardial injury is a significant predictor of mortality in hospitalized coronavirus disease 2019 (COVID-19) patients, and there is evidence of increased levels of natriuretic peptide B in hospitalized non-survivor COVID-19 patients. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Aug 2020]'
• Protein Families: Druggable Genome, Secreted Protein, Stem cell - Pluripotency