CARD15 (NOD2) (NM_022162) Human Recombinant Protein

CAT#: TP762260

Purified recombinant protein of Human nucleotide-binding oligomerization domain containing 2 (NOD2), Ala110-Asn409, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein NOD2 was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region(Ala110-Asn409) of NOD2
• Tag: N-His
• Predicted MW: 33.9 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50mM Tris, 8M Urea, pH8.0.
• Storage: Store at -80°C.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_071445
• Locus ID: 64127
• UniProt ID: Q9HC29
• Cytogenetics: 16q12.1
• Refseq Size: 4485
• Refseq ORF: 3120
• Synonyms: ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1; YAOS
• Summary: This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
• Protein Families: Druggable Genome
• Protein Pathways: NOD-like receptor signaling pathway