CARD15 (NOD2) (NM_022162) Human Recombinant Protein

CAT#: TP762260

Purified recombinant protein of Human nucleotide-binding oligomerization domain containing 2 (NOD2), Ala110-Asn409, with N-terminal His tag, expressed in E.coli, 50ug


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USD 205.00

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Size
    • 50 ug

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Specifications

Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
A DNA sequence encoding the region(Ala110-Asn409) of NOD2
Tag N-His
Predicted MW 33.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris, 8M Urea, pH8.0.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_071445
Locus ID 64127
UniProt ID Q9HC29
Cytogenetics 16q12.1
Refseq Size 4485
Refseq ORF 3120
Synonyms ACUG; BLAU; BLAUS; CARD15; CD; CLR16.3; IBD1; NLRC2; NOD2B; PSORAS1; YAOS
Summary This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Protein Families Druggable Genome
Protein Pathways NOD-like receptor signaling pathway

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