CLACP (COL25A1) (NM_198721) Human Recombinant Protein
CAT#: TP762281
Purified recombinant protein of Human collagen, type XXV, alpha 1 (COL25A1), transcript variant 1, Lys573-Gln653, with N-terminal His-ABP tag, expressed in E.coli, 50ug
Size: 25 Slides
Other products for "COL25A1"
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding the region(Lys573-Gln653) of COL25A1
|
Tag | N-His ABP |
Predicted MW | 23.5 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 50mM Tris, pH8.0, 8M Urea |
Storage | Store at -80°C after receiving vials. |
Stability | Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_942014 |
Locus ID | 84570 |
UniProt ID | Q9BXS0 |
Cytogenetics | 4q25 |
Refseq Size | 2607 |
Refseq ORF | 1962 |
Synonyms | AMY; CFEOM5; CLAC; CLAC-P; CLACP |
Summary | This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
Protein Families | Transmembrane |
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