P Glycoprotein (ABCB1) (NM_000927) Human Recombinant Protein
CAT#: TP762415
Purified recombinant protein of Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), Met1-Tyr50-GGGGS-Gly600-Ile700, with N-terminal His tag, expressed in E.coli, 50ug
Other products for "ABCB1"
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding the region (Met1-Tyr50-GGGGS-Gly600-Ile700) of ABCB1
|
Tag | N-His |
Predicted MW | 17.6 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | >80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 50mM Tris, pH8.0, 8M Urea |
Storage | Store at -80°C after receiving vials. |
Stability | Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_000918 |
Locus ID | 5243 |
UniProt ID | P08183, A4D1D2 |
Cytogenetics | 7q21.12 |
Refseq Size | 4872 |
Refseq ORF | 3840 |
Synonyms | ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1 |
Summary | 'The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]' |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways | ABC transporters |
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