GLRB (NM_000824) Human Recombinant Protein

CAT#: TP762425

Purified recombinant protein of Human glycine receptor, beta (GLRB), transcript variant 1, Met353-Lys471, with N-terminal His-ABP tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein GLRB was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region (Met353-Lys471) of GLRB
• Tag: N-His ABP
• Predicted MW: 28.1 kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: >80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_000815
• Locus ID: 2743
• UniProt ID: P48167
• Cytogenetics: 4q32.1
• Refseq Size: 3076
• Refseq ORF: 1491
• Synonyms: HKPX2
• Summary: 'This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]'
• Protein Families: Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction