ATP7B (NM_000053) Human Recombinant Protein

CAT#: TP762497

Purified recombinant protein of Human ATPase, Cu++ transporting, beta polypeptide (ATP7B), transcript variant 1, 200His-482Thr, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein ATP7B was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region (200His-482Thr) of ATP7B
• Tag: N-His
• Predicted MW: 31.9kDa
• Concentration: >50 ug/mL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, pH8.0, 150mM NaCl, 10% glycerol
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_000044
• Locus ID: 540
• UniProt ID: P35670, A0A024RDX3, B7ZLR4
• Cytogenetics: 13q14.3
• Refseq Size: 6644
• Refseq ORF: 4395
• Synonyms: PWD; WC1; WD; WND
• Summary: This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least 2 putative copper-binding sites. This protein is a monomer, and functions as a copper-transporting ATPase which exports copper out of the cells, such as the efflux of hepatic copper into the bile. Alternate transcriptional splice variants, encoding different isoforms with distinct cellular localizations, have been characterized. Mutations in this gene have been associated with Wilson disease which is characterized by copper accumulation. [provided by RefSeq, Dec 2019]
• Protein Families: Druggable Genome, Transmembrane