AGO1 (NM_012199) Human Recombinant Protein
CAT#: TP762603
Purified recombinant protein of Human eukaryotic translation initiation factor 2C, 1 (EIF2C1), full length, with N-terminal GST and C-terminal His tag, expressed in E.coli, 50ug
Other products for "AGO1"
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
A DNA sequence encoding the region full length of EIF2C1
|
Tag | N-GST and C-HIS |
Predicted MW | 97 kDa |
Concentration | >50 ug/mL as determined by microplate BCA method |
Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Buffer | 50mM Tris, pH8.0, 8M Urea |
Storage | Store at -80°C after receiving vials. |
Stability | Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Reference Data | |
RefSeq | NP_036331 |
Locus ID | 26523 |
UniProt ID | Q9UL18, B2RAD8 |
Cytogenetics | 1p34.3 |
Refseq Size | 7478 |
Refseq ORF | 2571 |
Synonyms | EIF2C; EIF2C1; GERP95; hAgo1; Q99 |
Summary | This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015] |
Protein Families | Druggable Genome |
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