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Target Symbol
- MAP2K1 (77)
- MAP2K3 (51)
- CTAG1B (50)
- PDCD1 (48)
- KLK8 (40)
- LIPG (40)
- CDKN2A (34)
- MAPK13 (34)
- MDM4 (31)
- EPCAM (29)
- ERCC1 (29)
- CD163 (27)
- SYP (27)
- VIM (27)
- ERBB2 (25)
- MLANA (25)
- PECAM1 (25)
- TP53 (24)
- CCT8L2 (22)
- SENP2 (22)
- CHGA (21)
- IDO1 (21)
- UBE2G2 (21)
- CD1C (20)
- MMP13 (20)
- NPR3 (20)
- ERG (19)
- PARVA (19)
- SNX9 (19)
- SPG7 (19)
- BSG (18)
- CTNNB1 (18)
- FOXI1 (18)
- L1CAM (18)
- PIK3R5 (18)
- PNMT (18)
- CD19 (17)
- HRAS (17)
- TH (17)
- ACAA2 (16)
- BTK (16)
- IGF2BP2 (16)
- LOX (16)
- PTPRE (16)
- RARRES1 (16)
- SAMHD1 (16)
- SIVA1 (16)
- APP (15)
- CATIP (15)
- FATE1 (15)
- IL1A (15)
- KRT7 (15)
- TLE1 (15)
- BTN1A1 (14)
- NKX2-1 (14)
- PDE4A (14)
- RAB30 (14)
- TUBB2B (14)
- BECN1 (13)
- FGF21 (13)
- GFAP (13)
- MCL1 (13)
- SOX17 (13)
- VWA5A (13)
- BRAF (12)
- CD33 (12)
- CMPK1 (12)
- CYP1A2 (12)
- FGFR2 (12)
- GADD45G (12)
- GATA3 (12)
- KIF25 (12)
- LIMK1 (12)
- MAPRE2 (12)
- NME4 (12)
- RAB37 (12)
- TACC3 (12)
- TAL1 (12)
- TRIM9 (12)
- ACAT2 (11)
- AFP (11)
- CD80 (11)
- CDK2 (11)
- ENG (11)
- FCGR2A (11)
- GBP2 (11)
- HDAC6 (11)
- MAPK7 (11)
- MIOX (11)
- MOB3B (11)
- MTRF1L (11)
- MUC1 (11)
- PDGFRB (11)
- PIK3AP1 (11)
- PIK3CG (11)
- PRKCE (11)
- PSMC3 (11)
- RPN1 (11)
- SMS (11)
- SNAP25 (11)
Knockout (KO) Validation
Families
- Druggable Genome (3138)
- Transmembrane (1038)
- Transcription Factors (684)
- Protein Kinase (481)
- ES Cell Differentiation/IPS (452)
- Secreted Protein (442)
- Protease (211)
- Stem cell - Pluripotency (163)
- Adult stem cells (72)
- Phosphatase (55)
- Embryonic stem cells (45)
- P450 (44)
- Stem cell relevant signaling - JAK/STAT signaling pathway (36)
- Ion Channels: Other (31)
- Stem cell relevant signaling - DSL/Notch pathway (29)
- Induced pluripotent stem cells (28)
- Cancer stem cells (25)
- Nuclear Hormone Receptor (22)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (19)
- GPCR (13)
- Stem cell relevant signaling - Wnt Signaling pathway (9)
- Ion Channels: Potassium (8)
Pathways
- Metabolic pathways (615)
- Pathways in cancer (468)
- MAPK signaling pathway (409)
- Fc epsilon RI signaling pathway (286)
- Toll-like receptor signaling pathway (285)
- Focal adhesion (281)
- Neurotrophin signaling pathway (275)
- Prostate cancer (272)
- T cell receptor signaling pathway (272)
- Pancreatic cancer (265)
- Chronic myeloid leukemia (263)
- Non-small cell lung cancer (259)
- Melanoma (253)
- Progesterone-mediated oocyte maturation (250)
- Endometrial cancer (243)
- ErbB signaling pathway (242)
- Glioma (239)
- Regulation of actin cytoskeleton (237)
- Bladder cancer (236)
- Insulin signaling pathway (234)
- Colorectal cancer (229)
- GnRH signaling pathway (229)
- B cell receptor signaling pathway (209)
- VEGF signaling pathway (202)
- Fc gamma R-mediated phagocytosis (201)
- Acute myeloid leukemia (199)
- Renal cell carcinoma (193)
- Gap junction (185)
- Chemokine signaling pathway (179)
- Thyroid cancer (178)
- Natural killer cell mediated cytotoxicity (174)
- Cell adhesion molecules (CAMs) (172)
- Leukocyte transendothelial migration (158)
- Cell cycle (146)
- Apoptosis (137)
- Amyotrophic lateral sclerosis (ALS) (135)
- Oocyte meiosis (130)
- p53 signaling pathway (130)
- Melanogenesis (129)
- Prion diseases (126)
- Long-term depression (123)
- Long-term potentiation (120)
- Jak-STAT signaling pathway (118)
- Hematopoietic cell lineage (117)
- Vascular smooth muscle contraction (117)
- Small cell lung cancer (106)
- Wnt signaling pathway (105)
- Purine metabolism (98)
- Dorso-ventral axis formation (91)
- Endocytosis (90)
- Type II diabetes mellitus (89)
- Tight junction (88)
- Alzheimer's disease (87)
- Adherens junction (84)
- Ubiquitin mediated proteolysis (83)
- Axon guidance (82)
- Huntington's disease (78)
- Parkinson's disease (77)
- mTOR signaling pathway (76)
- Pathogenic Escherichia coli infection (74)
- Epithelial cell signaling in Helicobacter pylori infection (72)
- Cytokine-cytokine receptor interaction (71)
- NOD-like receptor signaling pathway (70)
- Pyrimidine metabolism (70)
- Adipocytokine signaling pathway (67)
- Primary immunodeficiency (67)
- RIG-I-like receptor signaling pathway (65)
- Glycerolipid metabolism (59)
- Valine (58)
- leucine and isoleucine degradation (56)
- TGF-beta signaling pathway (54)
- Tryptophan metabolism (53)
- Glycolysis / Gluconeogenesis (51)
- Basal cell carcinoma (50)
- Nucleotide excision repair (50)
- Systemic lupus erythematosus (49)
- Tyrosine metabolism (47)
- Oxidative phosphorylation (46)
- Arginine and proline metabolism (45)
- Calcium signaling pathway (45)
- Graft-versus-host disease (45)
- Type I diabetes mellitus (43)
- Drug metabolism - cytochrome P450 (40)
- Arachidonic acid metabolism (39)
- Metabolism of xenobiotics by cytochrome P450 (37)
- Cytosolic DNA-sensing pathway (36)
- Fatty acid metabolism (36)
- PPAR signaling pathway (35)
- Phosphatidylinositol signaling system (34)
- Maturity onset diabetes of the young (33)
- Proteasome (33)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (30)
- Fructose and mannose metabolism (29)
- Pyruvate metabolism (28)
- Retinol metabolism (28)
- Glutathione metabolism (27)
- Linoleic acid metabolism (27)
- Citrate cycle (TCA cycle) (26)
- Inositol phosphate metabolism (26)
- Viral myocarditis (26)
- beta-Alanine metabolism (26)
- Antigen processing and presentation (25)
- Hypertrophic cardiomyopathy (HCM) (25)
- Propanoate metabolism (25)
- Butanoate metabolism (24)
- Glycine (24)
- serine and threonine metabolism (24)
- Base excision repair (22)
- Lysosome (22)
- Pentose phosphate pathway (22)
- Allograft rejection (21)
- Lysine degradation (21)
- Neuroactive ligand-receptor interaction (21)
- Regulation of autophagy (21)
- Amino sugar and nucleotide sugar metabolism (20)
- Complement and coagulation cascades (19)
- Cysteine and methionine metabolism (19)
- Dilated cardiomyopathy (19)
- Galactose metabolism (19)
- Mismatch repair (19)
- Notch signaling pathway (19)
- Autoimmune thyroid disease (18)
- RNA polymerase (18)
- Spliceosome (18)
- Vibrio cholerae infection (18)
- Terpenoid backbone biosynthesis (17)
- Fatty acid elongation in mitochondria (16)
- Synthesis and degradation of ketone bodies (16)
- Caffeine metabolism (15)
- Cardiac muscle contraction (15)
- Drug metabolism - other enzymes (15)
- RNA degradation (15)
- DNA replication (14)
- Glycosaminoglycan degradation (14)
- Starch and sucrose metabolism (13)
- Ascorbate and aldarate metabolism (12)
- Hedgehog signaling pathway (12)
- N-Glycan biosynthesis (12)
- SNARE interactions in vesicular transport (12)
- Sphingolipid metabolism (12)
- Nicotinate and nicotinamide metabolism (11)
- Non-homologous end-joining (10)
- One carbon pool by folate (10)
- Other glycan degradation (10)
- Alanine (9)
- Circadian rhythm - mammal (9)
- Folate biosynthesis (9)
- Homologous recombination (9)
- Renin-angiotensin system (9)
- aspartate and glutamate metabolism (9)
- ECM-receptor interaction (8)
- Histidine metabolism (8)
- Nitrogen metabolism (8)
- Primary bile acid biosynthesis (8)
- Glycosphingolipid biosynthesis - ganglio series (7)
- Glyoxylate and dicarboxylate metabolism (7)
- Porphyrin and chlorophyll metabolism (7)
- Sulfur metabolism (7)
- Asthma (6)
- Glycosphingolipid biosynthesis - lacto and neolacto series (6)
- Keratan sulfate biosynthesis (6)
- Methane metabolism (6)
- Pantothenate and CoA biosynthesis (6)
- Biosynthesis of unsaturated fatty acids (5)
- Fatty acid biosynthesis (4)
- Taurine and hypotaurine metabolism (4)
- Androgen and estrogen metabolism (3)
- Basal transcription factors (3)
- Glycerophospholipid metabolism (3)
- Olfactory transduction (3)
- Selenoamino acid metabolism (3)
- Vitamin B6 metabolism (3)
- Phenylalanine metabolism (2)
- Steroid biosynthesis (2)
- leucine and isoleucine biosynthesis (2)
- Aminoacyl-tRNA biosynthesis (1)
- Limonene and pinene degradation (1)
- Pentose and glucuronate interconversions (1)