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Target Symbol
- MAP2K1 (42)
- MAP2K3 (33)
- NPR3 (27)
- RAB21 (24)
- DNM1L (21)
- ERBB2 (18)
- LTA4H (18)
- PIK3R5 (18)
- ACAA2 (15)
- ACAT2 (15)
- CTNNB1 (15)
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- OTC (15)
- TBC1D21 (15)
- ABCB1 (12)
- AGR2 (12)
- BCL2 (12)
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- NRBP1 (12)
- OXSM (12)
- PCNA (12)
- PLK1 (12)
- PRKCE (12)
- SYT4 (12)
- ACSS2 (9)
- AKR1A1 (9)
- CDC123 (9)
- ESR1 (9)
- GPI (9)
- HOXC11 (9)
- ILVBL (9)
- JUN (9)
- LIMK1 (9)
- MAPK13 (9)
- MCM2 (9)
- NOG (9)
- PDE4A (9)
- PIK3C2A (9)
- PPP5C (9)
- RFXANK (9)
- SAMHD1 (9)
- TSC22D1 (9)
- AMDHD1 (6)
- APP (6)
- ARFGAP1 (6)
- ASH2L (6)
- CBWD1 (6)
- CHEK2 (6)
- CNOT2 (6)
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- CPA2 (6)
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- CPT1B (6)
- CRYAA (6)
- ERG (6)
- FAF1 (6)
- FBXW7 (6)
- GABRA5 (6)
- GARS (6)
- GATA3 (6)
- H2AFY2 (6)
- HNRNPM (6)
- IQGAP1 (6)
- KRT8 (6)
- KYNU (6)
- LCMT1 (6)
- MAP2K4 (6)
- MEF2C (6)
- MME (6)
- MYC (6)
- NLN (6)
- NNMT (6)
- NOTCH1 (6)
- NR3C1 (6)
- OSGIN2 (6)
- PARN (6)
- PDE4B (6)
- PGAM2 (6)
- PMEL (6)
- PRKD2 (6)
- PSMA2 (6)
- RAB30 (6)
- RAD21 (6)
- RPL7A (6)
- SAE1 (6)
- SERPINB1 (6)
- SMS (6)
- SNX9 (6)
- SOCS3 (6)
- SOX17 (6)
- SQSTM1 (6)
- SRSF9 (6)
- STK39 (6)
- SYP (6)
- TLE1 (6)
- TMOD1 (6)
- TRIM45 (6)
- TUBAL3 (6)
- TYMS (6)
Clonalities
Knockout (KO) Validation
Families
- Druggable Genome (1095)
- Transcription Factors (282)
- Protein Kinase (237)
- Transmembrane (231)
- ES Cell Differentiation/IPS (108)
- Protease (102)
- Stem cell - Pluripotency (96)
- Secreted Protein (69)
- Adult stem cells (18)
- Nuclear Hormone Receptor (18)
- Stem cell relevant signaling - JAK/STAT signaling pathway (18)
- Cancer stem cells (12)
- Embryonic stem cells (12)
- P450 (12)
- Stem cell relevant signaling - DSL/Notch pathway (12)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (12)
- Induced pluripotent stem cells (9)
- Phosphatase (9)
- Ion Channels: Cys-loop Receptors (6)
- Stem cell relevant signaling - Wnt Signaling pathway (6)
- GPCR (3)
- Ion Channels: Other (3)
- Ion Channels: Potassium (3)
Pathways
- Metabolic pathways (255)
- Pathways in cancer (180)
- MAPK signaling pathway (144)
- Focal adhesion (135)
- Fc epsilon RI signaling pathway (132)
- Prostate cancer (132)
- Colorectal cancer (123)
- Toll-like receptor signaling pathway (123)
- ErbB signaling pathway (120)
- Progesterone-mediated oocyte maturation (117)
- Endometrial cancer (114)
- Fc gamma R-mediated phagocytosis (108)
- Neurotrophin signaling pathway (108)
- GnRH signaling pathway (102)
- Non-small cell lung cancer (96)
- Pancreatic cancer (93)
- Regulation of actin cytoskeleton (93)
- Acute myeloid leukemia (90)
- Renal cell carcinoma (90)
- B cell receptor signaling pathway (87)
- T cell receptor signaling pathway (87)
- Chronic myeloid leukemia (84)
- Insulin signaling pathway (84)
- Melanoma (81)
- VEGF signaling pathway (81)
- Bladder cancer (78)
- Glioma (78)
- Chemokine signaling pathway (75)
- Thyroid cancer (75)
- Natural killer cell mediated cytotoxicity (72)
- Melanogenesis (69)
- Cell cycle (60)
- Oocyte meiosis (60)
- Amyotrophic lateral sclerosis (ALS) (57)
- Prion diseases (57)
- Vascular smooth muscle contraction (57)
- Gap junction (54)
- Leukocyte transendothelial migration (54)
- Purine metabolism (54)
- Wnt signaling pathway (54)
- Adherens junction (51)
- Dorso-ventral axis formation (51)
- Small cell lung cancer (51)
- Endocytosis (48)
- Long-term depression (48)
- Long-term potentiation (48)
- Type II diabetes mellitus (45)
- Fatty acid metabolism (42)
- Jak-STAT signaling pathway (42)
- Valine (42)
- leucine and isoleucine degradation (42)
- Apoptosis (39)
- Glycolysis / Gluconeogenesis (39)
- mTOR signaling pathway (36)
- Epithelial cell signaling in Helicobacter pylori infection (33)
- Phosphatidylinositol signaling system (33)
- Tight junction (33)
- Ubiquitin mediated proteolysis (33)
- Arginine and proline metabolism (30)
- Propanoate metabolism (30)
- Pyrimidine metabolism (30)
- Basal cell carcinoma (27)
- Pathogenic Escherichia coli infection (27)
- Pyruvate metabolism (27)
- Spliceosome (27)
- Arachidonic acid metabolism (24)
- Butanoate metabolism (24)
- Calcium signaling pathway (24)
- RNA degradation (24)
- Tryptophan metabolism (24)
- Alzheimer's disease (21)
- Axon guidance (21)
- Base excision repair (21)
- DNA replication (21)
- Lysine degradation (21)
- Primary immunodeficiency (21)
- Proteasome (21)
- TGF-beta signaling pathway (21)
- Adipocytokine signaling pathway (18)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (18)
- Fatty acid elongation in mitochondria (18)
- Renin-angiotensin system (18)
- Terpenoid backbone biosynthesis (18)
- p53 signaling pathway (18)
- Antigen processing and presentation (15)
- Drug metabolism - cytochrome P450 (15)
- Glutathione metabolism (15)
- Histidine metabolism (15)
- Inositol phosphate metabolism (15)
- Nucleotide excision repair (15)
- Synthesis and degradation of ketone bodies (15)
- beta-Alanine metabolism (15)
- ABC transporters (12)
- Amino sugar and nucleotide sugar metabolism (12)
- Caffeine metabolism (12)
- Drug metabolism - other enzymes (12)
- Fatty acid biosynthesis (12)
- Glycerolipid metabolism (12)
- Hedgehog signaling pathway (12)
- Mismatch repair (12)
- Neuroactive ligand-receptor interaction (12)
- Notch signaling pathway (12)
- One carbon pool by folate (12)
- Oxidative phosphorylation (12)
- Pentose phosphate pathway (12)
- RIG-I-like receptor signaling pathway (12)
- Retinol metabolism (12)
- Starch and sucrose metabolism (12)
- Tyrosine metabolism (12)
- Alanine (9)
- NOD-like receptor signaling pathway (9)
- Nicotinate and nicotinamide metabolism (9)
- Parkinson's disease (9)
- Vibrio cholerae infection (9)
- aspartate and glutamate metabolism (9)
- Aminoacyl-tRNA biosynthesis (6)
- Androgen and estrogen metabolism (6)
- Cell adhesion molecules (CAMs) (6)
- Cysteine and methionine metabolism (6)
- Cytokine-cytokine receptor interaction (6)
- Hematopoietic cell lineage (6)
- Huntington's disease (6)
- Lysosome (6)
- Metabolism of xenobiotics by cytochrome P450 (6)
- PPAR signaling pathway (6)
- Ribosome (6)
- Selenoamino acid metabolism (6)
- Systemic lupus erythematosus (6)
- Ascorbate and aldarate metabolism (3)
- Cardiac muscle contraction (3)
- Citrate cycle (TCA cycle) (3)
- Complement and coagulation cascades (3)
- Dilated cardiomyopathy (3)
- Folate biosynthesis (3)
- Fructose and mannose metabolism (3)
- Glycerophospholipid metabolism (3)
- Glyoxylate and dicarboxylate metabolism (3)
- Hypertrophic cardiomyopathy (HCM) (3)
- Limonene and pinene degradation (3)
- Linoleic acid metabolism (3)
- Maturity onset diabetes of the young (3)
- Nitrogen metabolism (3)
- Porphyrin and chlorophyll metabolism (3)
- Protein export (3)
- Regulation of autophagy (3)
- SNARE interactions in vesicular transport (3)
- Steroid biosynthesis (3)
- Sulfur metabolism (3)
- Taurine and hypotaurine metabolism (3)
- Thiamine metabolism (3)
- Type I diabetes mellitus (3)
- Vitamin B6 metabolism (3)