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Target Symbol
- MAP2K1 (34)
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Reactivities
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Knockout (KO) Validation
Assay Types
Families
- Druggable Genome (3160)
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- Secreted Protein (482)
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- Stem cell relevant signaling - DSL/Notch pathway (26)
- Stem cell relevant signaling - JAK/STAT signaling pathway (22)
- Ion Channels: Other (18)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (12)
- GPCR (9)
- Stem cell relevant signaling - Wnt Signaling pathway (5)
- Ion Channels: Cys-loop Receptors (3)
- Ion Channels: Transient receptor potential (3)
- Ion Channels: Potassium (2)
Pathways
- Metabolic pathways (647)
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- B cell receptor signaling pathway (157)
- Cell adhesion molecules (CAMs) (151)
- Regulation of actin cytoskeleton (149)
- Insulin signaling pathway (145)
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- Fc epsilon RI signaling pathway (141)
- Acute myeloid leukemia (134)
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- Renal cell carcinoma (120)
- Apoptosis (115)
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- Thyroid cancer (110)
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- Chemokine signaling pathway (105)
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- VEGF signaling pathway (102)
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- Small cell lung cancer (99)
- Purine metabolism (96)
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- Jak-STAT signaling pathway (95)
- p53 signaling pathway (95)
- Cytokine-cytokine receptor interaction (92)
- Melanogenesis (89)
- Oocyte meiosis (89)
- Alzheimer's disease (88)
- Pyrimidine metabolism (87)
- Amyotrophic lateral sclerosis (ALS) (84)
- Type II diabetes mellitus (81)
- Adherens junction (80)
- Gap junction (80)
- Huntington's disease (76)
- Glycolysis / Gluconeogenesis (71)
- mTOR signaling pathway (71)
- Arginine and proline metabolism (68)
- Ubiquitin mediated proteolysis (67)
- Prion diseases (65)
- Long-term depression (64)
- Complement and coagulation cascades (63)
- Primary immunodeficiency (63)
- Vascular smooth muscle contraction (63)
- Adipocytokine signaling pathway (62)
- Long-term potentiation (61)
- Lysosome (59)
- Glycerolipid metabolism (58)
- Valine (57)
- leucine and isoleucine degradation (57)
- Pathogenic Escherichia coli infection (54)
- Basal cell carcinoma (53)
- Calcium signaling pathway (53)
- Parkinson's disease (52)
- Antigen processing and presentation (50)
- Drug metabolism - cytochrome P450 (50)
- Nucleotide excision repair (50)
- Dorso-ventral axis formation (49)
- Phosphatidylinositol signaling system (49)
- Fatty acid metabolism (47)
- Metabolism of xenobiotics by cytochrome P450 (47)
- Oxidative phosphorylation (45)
- Tight junction (45)
- Epithelial cell signaling in Helicobacter pylori infection (44)
- Systemic lupus erythematosus (44)
- Tryptophan metabolism (44)
- Arachidonic acid metabolism (43)
- Axon guidance (42)
- Inositol phosphate metabolism (42)
- Lysine degradation (42)
- Autoimmune thyroid disease (41)
- DNA replication (39)
- Propanoate metabolism (39)
- ECM-receptor interaction (38)
- PPAR signaling pathway (38)
- RIG-I-like receptor signaling pathway (38)
- TGF-beta signaling pathway (38)
- Butanoate metabolism (36)
- Alanine (35)
- Dilated cardiomyopathy (35)
- Mismatch repair (35)
- RNA degradation (35)
- aspartate and glutamate metabolism (35)
- Glutathione metabolism (34)
- Glycine (33)
- Histidine metabolism (33)
- Hypertrophic cardiomyopathy (HCM) (33)
- Spliceosome (33)
- serine and threonine metabolism (33)
- Base excision repair (32)
- Pyruvate metabolism (31)
- Retinol metabolism (31)
- Cytosolic DNA-sensing pathway (30)
- One carbon pool by folate (28)
- Type I diabetes mellitus (28)
- Tyrosine metabolism (28)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (27)
- Renin-angiotensin system (27)
- Homologous recombination (26)
- Proteasome (26)
- Viral myocarditis (26)
- NOD-like receptor signaling pathway (25)
- Pentose phosphate pathway (25)
- beta-Alanine metabolism (25)
- ABC transporters (24)
- Allograft rejection (23)
- Hedgehog signaling pathway (23)
- Amino sugar and nucleotide sugar metabolism (22)
- Circadian rhythm - mammal (22)
- Starch and sucrose metabolism (22)
- Cardiac muscle contraction (21)
- Cysteine and methionine metabolism (20)
- Drug metabolism - other enzymes (20)
- Linoleic acid metabolism (20)
- Fructose and mannose metabolism (19)
- Neuroactive ligand-receptor interaction (19)
- Notch signaling pathway (19)
- Vibrio cholerae infection (19)
- Terpenoid backbone biosynthesis (18)
- Fatty acid elongation in mitochondria (17)
- Graft-versus-host disease (17)
- Nicotinate and nicotinamide metabolism (17)
- Sulfur metabolism (17)
- Aminoacyl-tRNA biosynthesis (15)
- Folate biosynthesis (15)
- Galactose metabolism (15)
- Caffeine metabolism (14)
- Citrate cycle (TCA cycle) (14)
- Maturity onset diabetes of the young (13)
- N-Glycan biosynthesis (13)
- Sphingolipid metabolism (13)
- Nitrogen metabolism (12)
- SNARE interactions in vesicular transport (12)
- Synthesis and degradation of ketone bodies (12)
- Glycerophospholipid metabolism (11)
- Asthma (10)
- Other glycan degradation (10)
- Primary bile acid biosynthesis (10)
- Regulation of autophagy (10)
- Methane metabolism (9)
- Ribosome (9)
- Selenoamino acid metabolism (9)
- Non-homologous end-joining (8)
- Phenylalanine metabolism (8)
- Porphyrin and chlorophyll metabolism (8)
- Glyoxylate and dicarboxylate metabolism (7)
- RNA polymerase (7)
- Taste transduction (7)
- Cyanoamino acid metabolism (6)
- Glycosaminoglycan degradation (6)
- Androgen and estrogen metabolism (5)
- Ascorbate and aldarate metabolism (5)
- Pantothenate and CoA biosynthesis (5)
- Biosynthesis of unsaturated fatty acids (4)
- Fatty acid biosynthesis (4)
- Limonene and pinene degradation (4)
- Steroid biosynthesis (4)
- Vitamin B6 metabolism (4)
- Ether lipid metabolism (3)
- Glycosphingolipid biosynthesis - ganglio series (3)
- Olfactory transduction (3)
- Pentose and glucuronate interconversions (3)
- Taurine and hypotaurine metabolism (3)
- D-Glutamine and D-glutamate metabolism (2)
- Glycosphingolipid biosynthesis - lacto and neolacto series (2)
- Keratan sulfate biosynthesis (2)
- O-Glycan biosynthesis (2)
- Thiamine metabolism (2)
- Basal transcription factors (1)
- Biotin metabolism (1)
- C21-Steroid hormone metabolism (1)
- Glycosphingolipid biosynthesis - globo series (1)
- Protein export (1)
- Riboflavin metabolism (1)
- leucine and isoleucine biosynthesis (1)