Active filters
Families
- Druggable Genome
Filter by
Target Symbol
- NR1I3 (48)
- PDE9A (36)
- BDNF (34)
- CHRM2 (28)
- AMZ2 (22)
- ANAPC11 (22)
- CD59 (22)
- TGIF1 (22)
- TPM1 (22)
- HMGA1 (20)
- NRG1 (20)
- SERPINA1 (20)
- AURKA (18)
- FGFR1 (18)
- PPP2R2B (18)
- RAD17 (18)
- S100A13 (18)
- CACNB2 (16)
- CAMK2B (16)
- CD1E (16)
- CTSB (16)
- DTNA (16)
- OGG1 (16)
- APTX (14)
- ARSA (14)
- CREM (14)
- CSF2RA (14)
- DCX (14)
- EYA1 (14)
- FGL1 (14)
- FOLR1 (14)
- GABRA1 (14)
- HNRNPD (14)
- HOMER2 (14)
- KCNIP2 (14)
- KCNIP4 (14)
- MGST1 (14)
- MME (14)
- NTRK2 (14)
- OPRM1 (14)
- OPTN (14)
- P2RX2 (14)
- PAX2 (14)
- PAX3 (14)
- PTPA (14)
- RASSF1 (14)
- RBFOX2 (14)
- TCF7L2 (14)
- TRPV1 (14)
- AGL (12)
- BCL2L14 (12)
- CASP7 (12)
- CERKL (12)
- CLDN14 (12)
- DGKA (12)
- DTX2 (12)
- FBXO44 (12)
- FHL2 (12)
- IL5RA (12)
- MAPKAP1 (12)
- MAPT (12)
- NEK6 (12)
- NME2 (12)
- P2RY6 (12)
- PAK4 (12)
- PAX8 (12)
- PRKAR1B (12)
- RAB27A (12)
- SIGLEC6 (12)
- STRADA (12)
- TNNT2 (12)
- ACRV1 (10)
- ALDH1A2 (10)
- ALDOA (10)
- ANXA2 (10)
- ASGR2 (10)
- ATXN3 (10)
- BACE1 (10)
- BAG6 (10)
- BCAP29 (10)
- BCAT1 (10)
- CA1 (10)
- CA10 (10)
- CAMK2D (10)
- CAMKK2 (10)
- CASP1 (10)
- CCL15 (10)
- CD151 (10)
- CELF1 (10)
- CKMT2 (10)
- CLEC7A (10)
- COMMD5 (10)
- CSF1 (10)
- CSNK1G3 (10)
- CTNNB1 (10)
- DDR1 (10)
- DHRS9 (10)
- FGFR4 (10)
- FGR (10)
- GBA (10)
Species
Expression Hosts
Pathways
- Metabolic pathways (1462)
- Pathways in cancer (924)
- MAPK signaling pathway (740)
- Cytokine-cytokine receptor interaction (662)
- Neuroactive ligand-receptor interaction (594)
- Regulation of actin cytoskeleton (500)
- Focal adhesion (496)
- Chemokine signaling pathway (478)
- Neurotrophin signaling pathway (434)
- Calcium signaling pathway (424)
- Jak-STAT signaling pathway (372)
- Wnt signaling pathway (362)
- Insulin signaling pathway (354)
- Progesterone-mediated oocyte maturation (322)
- ErbB signaling pathway (314)
- T cell receptor signaling pathway (314)
- Cell cycle (306)
- Purine metabolism (294)
- Natural killer cell mediated cytotoxicity (290)
- Endocytosis (288)
- Hematopoietic cell lineage (285)
- Prostate cancer (280)
- Toll-like receptor signaling pathway (280)
- GnRH signaling pathway (278)
- Oocyte meiosis (278)
- Axon guidance (273)
- Apoptosis (272)
- Colorectal cancer (264)
- Alzheimer's disease (254)
- Pancreatic cancer (250)
- Ubiquitin mediated proteolysis (244)
- Adherens junction (240)
- Leukocyte transendothelial migration (240)
- Melanogenesis (238)
- Tight junction (238)
- Renal cell carcinoma (224)
- Small cell lung cancer (224)
- Vascular smooth muscle contraction (222)
- Fc epsilon RI signaling pathway (218)
- Lysosome (218)
- Gap junction (216)
- Melanoma (216)
- TGF-beta signaling pathway (216)
- Chronic myeloid leukemia (212)
- VEGF signaling pathway (212)
- Glioma (210)
- Dilated cardiomyopathy (208)
- Huntington's disease (206)
- B cell receptor signaling pathway (204)
- Cell adhesion molecules (CAMs) (204)
- Hypertrophic cardiomyopathy (HCM) (202)
- Adipocytokine signaling pathway (200)
- Acute myeloid leukemia (196)
- Fc gamma R-mediated phagocytosis (192)
- Non-small cell lung cancer (188)
- Endometrial cancer (186)
- Long-term potentiation (186)
- Complement and coagulation cascades (176)
- NOD-like receptor signaling pathway (176)
- Phosphatidylinositol signaling system (176)
- p53 signaling pathway (176)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (172)
- Long-term depression (170)
- Olfactory transduction (152)
- Amyotrophic lateral sclerosis (ALS) (150)
- RIG-I-like receptor signaling pathway (150)
- ECM-receptor interaction (147)
- Epithelial cell signaling in Helicobacter pylori infection (146)
- Glycolysis / Gluconeogenesis (143)
- PPAR signaling pathway (142)
- Bladder cancer (134)
- Type II diabetes mellitus (126)
- mTOR signaling pathway (124)
- Pathogenic Escherichia coli infection (122)
- Thyroid cancer (122)
- Cardiac muscle contraction (120)
- Drug metabolism - cytochrome P450 (118)
- Inositol phosphate metabolism (118)
- Antigen processing and presentation (116)
- Metabolism of xenobiotics by cytochrome P450 (114)
- Basal cell carcinoma (108)
- Cytosolic DNA-sensing pathway (106)
- Valine (105)
- Hedgehog signaling pathway (104)
- Glycerophospholipid metabolism (100)
- Pyrimidine metabolism (100)
- Retinol metabolism (100)
- Arginine and proline metabolism (98)
- Viral myocarditis (96)
- Glycerolipid metabolism (93)
- Base excision repair (92)
- Primary immunodeficiency (92)
- Parkinson's disease (90)
- leucine and isoleucine degradation (87)
- Drug metabolism - other enzymes (82)
- Nucleotide excision repair (82)
- Fatty acid metabolism (79)
- Arachidonic acid metabolism (78)
- Vibrio cholerae infection (78)
- Fructose and mannose metabolism (76)
- Prion diseases (76)
- SNARE interactions in vesicular transport (76)
- Sphingolipid metabolism (76)
- Tyrosine metabolism (76)
- Taste transduction (74)
- Pyruvate metabolism (73)
- Autoimmune thyroid disease (72)
- Glutathione metabolism (72)
- Starch and sucrose metabolism (70)
- Lysine degradation (69)
- Notch signaling pathway (68)
- Systemic lupus erythematosus (66)
- Tryptophan metabolism (65)
- Proteasome (64)
- Butanoate metabolism (63)
- Amino sugar and nucleotide sugar metabolism (62)
- Galactose metabolism (62)
- Cysteine and methionine metabolism (56)
- Pentose phosphate pathway (56)
- Regulation of autophagy (56)
- Histidine metabolism (55)
- Alanine (54)
- Nitrogen metabolism (54)
- aspartate and glutamate metabolism (54)
- Linoleic acid metabolism (52)
- Type I diabetes mellitus (52)
- Propanoate metabolism (51)
- Androgen and estrogen metabolism (50)
- Homologous recombination (50)
- Maturity onset diabetes of the young (48)
- Ether lipid metabolism (46)
- Oxidative phosphorylation (46)
- Ribosome (46)
- Dorso-ventral axis formation (44)
- Renin-angiotensin system (44)
- Citrate cycle (TCA cycle) (42)
- Mismatch repair (42)
- Porphyrin and chlorophyll metabolism (42)
- Allograft rejection (40)
- Pantothenate and CoA biosynthesis (40)
- beta-Alanine metabolism (39)
- DNA replication (38)
- Riboflavin metabolism (38)
- Aminoacyl-tRNA biosynthesis (36)
- Glycosaminoglycan degradation (36)
- Phenylalanine metabolism (36)
- Spliceosome (36)
- ABC transporters (32)
- Glycine (32)
- Other glycan degradation (32)
- Selenoamino acid metabolism (32)
- serine and threonine metabolism (32)
- C21-Steroid hormone metabolism (30)
- Graft-versus-host disease (30)
- Non-homologous end-joining (30)
- leucine and isoleucine biosynthesis (30)
- Circadian rhythm - mammal (28)
- N-Glycan biosynthesis (28)
- Primary bile acid biosynthesis (28)
- Asthma (26)
- Basal transcription factors (24)
- Folate biosynthesis (24)
- alpha-Linolenic acid metabolism (24)
- Steroid biosynthesis (22)
- Terpenoid backbone biosynthesis (22)
- Ascorbate and aldarate metabolism (19)
- Limonene and pinene degradation (19)
- Glycosphingolipid biosynthesis - globo series (18)
- Pentose and glucuronate interconversions (18)
- Synthesis and degradation of ketone bodies (18)
- Thiamine metabolism (18)
- Glycosphingolipid biosynthesis - lacto and neolacto series (16)
- Glyoxylate and dicarboxylate metabolism (16)
- RNA degradation (16)
- Sulfur metabolism (16)
- Ubiquinone and other terpenoid-quinone biosynthesis (16)
- Nicotinate and nicotinamide metabolism (14)
- One carbon pool by folate (14)
- Biosynthesis of unsaturated fatty acids (10)
- Caffeine metabolism (10)
- Fatty acid elongation in mitochondria (8)
- Methane metabolism (8)
- RNA polymerase (8)
- Taurine and hypotaurine metabolism (8)
- Fatty acid biosynthesis (6)
- Glycosphingolipid biosynthesis - ganglio series (6)
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (6)
- Heparan sulfate biosynthesis (6)
- O-Glycan biosynthesis (6)
- Phenylalanine (6)
- Protein export (6)
- tyrosine and tryptophan biosynthesis (6)
- Vitamin B6 metabolism (4)
- Biotin metabolism (2)
- Chondroitin sulfate biosynthesis (2)
- D-Arginine and D-ornithine metabolism (2)
- D-Glutamine and D-glutamate metabolism (2)
- Keratan sulfate biosynthesis (2)