shRNA Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
HDAC8 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206, 2011 Jan shRNA TR304143
HECTD1 HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition Int J Oncol, 2020 Feb shRNA TF304134
HES1 Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells Blood, Aug 2013; 122: 1162 - 1173., 2013 Aug shRNA TG312478
HES1 Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression Blood, Mar 2011; 117: 2891 - 2900, 2011 Mar shRNA TR312478
HES5 Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development Development. 2013 Dec;140(23):4751-62, 2013 Oct shRNA TG312477
Hes5 Histone methyltransferase enhancer of zeste homolog 2 regulates Schwann cell differentiation. Glia, 2013 Feb shRNA TG711044
HEXIM1 Identification of HEXIM1 as a Positive Regulator of p53 J. Biol. Chem., Oct 2012; 287: 36443 - 36454., 2012 Oct shRNA TG312473
HHEX A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition Cancer Res., 2019 Dec shRNA TR312464
HHEX PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin Oncogene, 2013 Nov shRNA TG312464
HHEX DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers Nucleic Acids Res., Jul 2010; 10.1093/nar/gkq659., 2010 Jul shRNA TR312464
HHEX PRH/HHex controls cell survival through coordinate transcriptional regulation of VEGF signalling Mol. Cell. Biol., May 2010; 30: 2120 - 2134, 2010 May shRNA TR312464
HHIP Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms Blood Cancer Journal 2, e87 doi:10.1038/bcj.2012.36, 2012 Sep shRNA TR304118
HIF1A Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer Journal of Experimental & Clinical Cancer Research : CR, 2022 Aug shRNA TL320380
HIF1A ERK regulates HIF-1α-mediated platinum resistance by directly targeting PHD2 in ovarian cancer Clin. Cancer Res., 2019 Jul shRNA TG320380
Hif1a Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia Oncogene, 2017 Nov shRNA TR517255
HIF1A Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease J. Cell. Mol. Med., 2017 Apr shRNA TR320380
HIF1A Hypoxic niche-mediated regeneration of hematopoiesis in the engraftment window is dominantly affected by oxygen tension in the milieu Stem Cells Dev., 2015 Jun shRNA TF517255
HIF1A Hypoxia-Sensitive Epigenetic Regulation of an Antisense-Oriented lncRNA Controls WT1 Expression in Myeloid Leukemia Cells PLoS ONE, 2015 Mar shRNA TR320380
HIF1A Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells FASEB J., 2014 Nov shRNA TG320380
HIF1A A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth Through HIF-1/2a J. Biol. Chem., 2014 Nov shRNA TG320380
HIF1A The dual PI3K/mTOR inhibitor NVP-BEZ235 prevents epithelial-mesenchymal transition induced by hypoxia and TGF-β1 Eur. J. Pharmacol., Feb 2014., 2014 Feb shRNA TG320380
HIF1A Tirapazamine Sensitizes Hepatocellular Carcinoma Cells to Topoisomerase I Inhibitors via Cooperative Modulation of Hypoxia-Inducible Factor-1a Mol. Cancer Ther. Dec 2013., 2013 Dec shRNA TG320380
Hif1a Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells. Journal of neuroscience research, 2010 Sep shRNA TR517255
HIF1A Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion British Journal of Cancer (15 December 2009) doi:10.1038/sj.bjc.6605486 Full Paper, 2009 Dec shRNA TR320380
HIF1A Role of HIF-1 and NF-B Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals J. Biol. Chem., Jul 2008; 283: 20674 - 20686, 2008 Jul shRNA TR517255
HIP1 HIP1 mediates oncogenic transformation and cancer progression through STAT3 signalling bioRxiv, 2020 Jul shRNA TR312457
HIRA Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth Human genetics, 2021 Jan shRNA TF500962
HK2 Regulation of VDAC trafficking modulates cell death Cell Death Discov, 2016 Dec shRNA TR312415
HLA-DRA CIITA enhances HIV-1 attachment to CD4+ T cells leading to enhanced infection and cell depletion. Journal of immunology (Baltimore, Md. : 1950), 2011 Jan shRNA TG304088
HLA-DRA CIITA Enhances HIV-1 Attachment to CD4+ T Cells Leading to Enhanced Infection and Cell Depletion J. Immunol., Dec 2010; 185: 6480 - 6488, 2010 Dec shRNA TG304088
HMGA2 Chaperoning HMGA2 Protein Protects Stalled Replication Forks in Stem and Cancer Cells Cell Rep, Feb 2014., 2014 Feb shRNA TR319507
HMGB1 Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells Scientific Reports, 2022 Jan shRNA TL316576
HMGB1 HMGB1 contributes to adriamycin-induced cardiotoxicity via up-regulating autophagy Toxicol. Lett., 2018 Aug shRNA TG316576
HMGB1 Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells Mol Med Rep, 2017 Jan shRNA TG316576
HMGB1 HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells Mol Med Rep, 2016 May shRNA TG316576
HMGB1 Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis Tumour Biol., 2015 Jun shRNA TG316576
HMGB1 Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue PLoS One. 2013 Sep 20;8(9):e76039, 2013 Sep shRNA TR316576
HMGCS2 Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate J. Lipid Res., Mar 2013; 54: 592 - 601., 2013 Mar shRNA TR312391
HMGCS2 Human HMGCS2 Regulates Mitochondrial Fatty Acid Oxidation and FGF21 Expression in HepG2 Cell Line J. Biol. Chem., Jun 2011; 286: 20423 - 20430, 2011 Jun shRNA TR312391
HMGN2 Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells J. Biol. Chem, 2016 Dec shRNA TF319505
HMOX1 Hypoxia‐induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase‐1 in multiple myeloma Cancer Medicine, 2023 Feb shRNA TL312388
HMOX1 4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression Oncotarget, 2017 Jan shRNA TR312388
HMOX1 The Flavonoid, Eriodictyol, Induces Long-term Protection in ARPE-19 Cells through Its Effects on Nrf2 Activation and Phase 2 Gene Expression Invest. Ophthalmol. Vis. Sci., May 2009; 50: 2398 - 2406., 2009 May shRNA TR312388
Hmox2 Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing FASEB J., 2014 Oct shRNA TR514171
HNF1B Inhibition of Cell Death and Induction of G2 Arrest Accumulation in Human Ovarian Clear Cells by HNF-1ß Transcription Factor: Chemosensitivity Is Regulated by Checkpoint Kinase CHK1 Int. J. Gynecol. Cancer, 2014 Jun shRNA TG308907
HNF4A Modification in Oxidative Stress, Inflammation, and Lipoprotein Assembly in Response to Hepatocyte Nuclear Factor 4{alpha} Knockdown in Intestinal Epithelial Cells J. Biol. Chem., Dec 2010; 285: 40448 - 40460, 2010 Dec shRNA TR320382
HNRNPC The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene Mol. Cell. Biol., Nov 2008; 28: 6929 - 6938, 2008 Nov shRNA TR304074
HNRNPK Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK PNAS, Jul 2013; 110: 11624 - 11629., 2013 Jul shRNA TG712371
HNRNPL HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells Sci Rep, 2016 Nov shRNA TG312371
HNRNPL Separate cis-trans Pathways Post-transcriptionally Regulate Murine CD154 (CD40 Ligand) Expression: A NOVEL FUNCTION FOR CA REPEATS IN THE 3'-UNTRANSLATED REGION J. Biol. Chem., Sep 2008; 283: 25606 - 25616, 2008 Sep shRNA TR312371