shRNA Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
Lcn2 Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res., 2016 Sep shRNA MR226233
LCN2 Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells PLoS ONE, 2016 May shRNA TG311777
LCN2 Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant Free radical Research, 2016 Feb shRNA TG311777
LDHA Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s Cell Rep, 2020 Feb shRNA TG515372
Leap2 Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline JCI Insight, 2023 May shRNA TR519691
LEF1 MicroRNAs Regulate Pituitary Development, and MicroRNA 26b Specifically Targets Lymphoid Enhancer Factor 1 (Lef-1), Which Modulates Pituitary Transcription Factor 1 (Pit-1) Expression J. Biol. Chem., Nov 2010; 285: 34718 - 34728, 2010 Nov shRNA TR712526
LEO1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111., 2012 Oct shRNA TG303551
LEO1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145., 2012 Sep shRNA TR303551
LETM1 LETM1-mediated K+ and Na+ homeostasis regulates mitochondrial Ca2+ efflux Frontiers in Physiology, 2017 Nov shRNA TR311758
LGR5 FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells Biochem. Biophys. Res. Commun., 2017 Nov shRNA TF311747
LIMK1 Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects Nature Medicine 18, 1087-1094 doi:10.1038/nm.2834, 2012 Jun shRNA TR320403
LINC00261 LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response Cancer Res., 2019 Feb shRNA HC137604
LINC00504 The LINC00504/Mir-4739/KLK4 Axis Facilitates Cell Proliferation and Suppresses Cell Apoptosis Through Triggering The Wnt/Β-Catenin Pathway In Triple-Negative Breast Cancer Cells Research Square, 2020 Dec shRNA TR318094
LMBRD1 LMBD1 protein participates in cell mitosis by regulating microtubule assembly The Biochemical journal, 2021 Jun shRNA TF303512
LMNA Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells PLoS ONE, 2017 Apr shRNA TG303510
LMO1 LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer Oncotarget, 2018 Jul shRNA TG311708
LNP1 Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions J. Biol. Chem., 2016 Jul shRNA TR320968
LOC298795 Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation Oncotarget, 2014 Oct shRNA TL702077
LOXL2 Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane Blood, Oct 2011; 118: 3979 - 3989., 2011 Oct shRNA TR311699
LPAR1 High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells Cell. Physiol. Biochem., 2018 Oct shRNA TR313300
LPAR1 Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells Experimental Cell Research, 2017 Feb shRNA TR313300
LPAR1 Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells Mol. Carcinog., 2015 Sep shRNA TF712271
Lpar1 LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs Mol. Cell. Biochem., 2015 Jun shRNA TG509224
LPAR2 Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA2) and LPA3 in osteosarcoma cells Experimental and molecular pathology, 2020 Dec shRNA TG313298
LPAR2 Different effects of lysophosphatidic acid receptor-2 (LPA2) and LPA5 on the regulation of chemoresistance in colon cancer cells J. Recept. Signal Transduct. Res., 2020 Jul shRNA TG313298
LPAR2 Lysophosphatidic acid receptor-2 (LPA2)-mediated signaling enhances chemoresistance in melanoma cells treated with anticancer drugs Mol. Cell. Biochem., 2020 Apr shRNA TG313298
LPAR2 Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells Exp. Cell Res., 2018 May shRNA TR313298
LPAR2 Enhanced cellular functions through induction of LPA2 by cisplatin in fibrosarcoma HT1080 cells Mol. Cell. Biochem, 2017 Feb shRNA TR313298
Lpar2 LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs Mol. Cell. Biochem., 2015 Jun shRNA TG502984
Lpar3 Effects of lysophosphatidic acid (LPA) receptor-2 (LPA2) and LPA3 on the regulation of chemoresistance to anticancer drug in lung cancer cells Cell. Signal., 2020 Feb shRNA TG517410
LPAR3 High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells Cell. Physiol. Biochem., 2018 Oct shRNA TR313295
LPAR3 Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells Experimental Cell Research, 2017 Feb shRNA TR313295
LPAR3 Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells Mol. Carcinog., 2015 Sep shRNA TG710942
Lpar3 LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs Mol. Cell. Biochem., 2015 Jun shRNA TG517410
LPAR4 Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells Biochem. Biophys. Res. Commun, 2016 Dec shRNA TR312652
LPAR4 Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Biochem. Biophys. Res. Commun., 2015 Apr shRNA TF312652
LPAR5 Different effects of lysophosphatidic acid receptor-2 (LPA2) and LPA5 on the regulation of chemoresistance in colon cancer cells J. Recept. Signal Transduct. Res., 2020 Jul shRNA TG304222
LPAR5 LPA5-mediated signaling induced by endothelial cells and anticancer drug regulates cellular functions of osteosarcoma cells Experimental Cell Research, 2020 Jan shRNA TG304222
LPAR5 Modulation of chemoresistance by lysophosphatidic acid (LPA) signaling through LPA5 in melanoma cells treated with anticancer drugs Biochem. Biophys. Res. Commun., 2019 Jul shRNA TG304222
LPAR5 Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Biochem. Biophys. Res. Commun., 2015 Apr shRNA TG304222
LPAR5 Inhibitory effects of lysophosphatidic acid receptor-5 on cellular functions of sarcoma cells Growth Factors, 2014 May shRNA TG304222
LPAR5 Lysophosphatidic acid receptor-5 negatively regulates cell motile and invasive activities of human sarcoma cell lines Mol. Cell. Biochem. March 2014, 2014 Mar shRNA TG304222
Lpar5 Lysophosphatidic acid receptor-5 negatively regulates cellular responses in mouse fibroblast 3T3 cells Biochem. Biophys. Res. Commun., 2014 Mar shRNA TG304222
LPAR6 Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells Biochem. Biophys. Res. Commun, 2016 Dec shRNA TR310642
LPAR6 Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Biochem. Biophys. Res. Commun., 2015 Apr shRNA TF310642
Lpcat1 Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (Lpcat1) Catalyzes Histone Protein O -Palmitoylation to Regulate mRNA Synthesis The Journal of Biological Chemistry, 2011 Aug shRNA TL704171
LRP10 Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes RNA, 2010 Feb shRNA TL311681
LRP6 Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis Research Square, 2021 Feb shRNA TG509944
LRP6 RASSF10 suppresses lung cancer proliferation and invasion by decreasing the level of phosphorylated LRP6 Mol. Carcinog., 2019 Mar shRNA TG311676
Lrrfip1 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nature immunology, 2010 Jun shRNA TL514790