shRNA Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
PLCG1 CCR7/CCL21 Migration on Fibronectin Is Mediated by Phospholipase C{gamma}1 and ERK1/2 in Primary T Lymphocytes J. Biol. Chem., Dec 2010; 285: 38781 - 38787, 2010 Dec shRNA TF302445
Pld1 Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP 3 -Evoked Ca 2+ Signals through Sigma-1 Receptors Cell Reports, 2019 Jan shRNA TF711124
Pld2 Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP 3 -Evoked Ca 2+ Signals through Sigma-1 Receptors Cell Reports, 2019 Jan shRNA TF711696
PLD2 Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment Oncogene, 2018 Oct shRNA TR511484
Pld3 Rare coding variants in Phospholipase D3 (PLD3) confer risk for Alzheimer's disease Nature, 2014 Jul shRNA TL501676
PLD3 Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Nature Dec 2013., 2013 Dec shRNA TG310364
PLD3 Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Nature Dec 2013., 2013 Dec shRNA TG501676
PLK1 PLK1 inhibition downregulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster J. Biol. Chem., 2014 Dec shRNA TG320457
PLK1 PLK1 Inhibitors Synergistically Potentiate HDAC Inhibitor Lethality in Imatinib Mesylate–Sensitive or –Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo Clin. Cancer Res., Jan 2013; 19: 404 - 414., 2013 Jan shRNA TG320457
PLK1 Centrosomal Protein 55 (Cep55) Stability Is Negatively Regulated by p53 Protein through Polo-like Kinase 1 (Plk1) J. Biol. Chem., Feb 2012; 287: 4376 - 4385., 2012 Feb shRNA TR320457
PLOD3 Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression Mol. Cell. Probes, 2020 Jun shRNA TR310350
PLPP3 Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development Cardiovasc. Res., 2016 Apr shRNA TG302357
Plpp6 Role of Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) In Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes Drug Metab. Dispos., 2015 Dec shRNA TR703334
PLXNA1 The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells Cancer Res., Feb 2009; 69: 1485 - 1493, 2009 Feb shRNA TR302406
Pmaip1 Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation Mucosal Immunol, 2018 Jan shRNA TR512752
PMAIP1 NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5 Int. J. Oncol., 2015 Jun shRNA TR318983
Pnpla8 H2O2-activated mitochondrial phospholipase iPLA2? prevents lipotoxic oxidative stress in synergy with UCP2, amplifies signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic ß-cells Antioxid. Redox Signal., 2015 Apr shRNA TG706565
PODXL High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2 Biochem. Biophys. Res. Commun., 2016 Jul shRNA TG310316
PODXL Methylation of an intronic region regulates miR-199a in testicular tumor malignancy Oncogene (7 March 2011) doi:10.1038/onc.2011.60 Original Article, 2011 Mar shRNA TR310316
Pofut1 Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation. Analytical biochemistry, 2022 Sep shRNA TG506022
POLD3 Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney Am J Physiol Renal Physiol, Dec 2012; 303: F1629 - F1640., 2012 Dec shRNA TG310310
PON1 Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells Oncotarget, 2017 Apr shRNA TR310286
Positive Control An integrated transcriptomics-guided genome-wide promoter analysis and next-generation proteomics approach to mine factor(s) regulating cellular differentiation DNA Res, 2017 Jan shRNA TR30002
POU1F1 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus J. Clin. Invest., 2016 Feb shRNA TG310279
POU2F1 Epigenetic events involved in OCT1-dependent impaired response of hepatocellular carcinoma to sorafenib Br. J. Pharmacol., 2018 Dec shRNA TF310277
POU2F1 Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal Nature Communications, 2016 Jul shRNA TL310277
POU2F3 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus The Journal of Clinical Investigation, 2016 May shRNA TG310275
POU5F1 OCT4 accelerates tumorigenesis through activating JAK/STAT signaling in ovarian cancer side population cells Cancer Manag Res, 2019 Dec shRNA TR310267
POU5F1 MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells Tumour Biol., 2014 Jun shRNA TF310267
POU5F1 OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation Cell Death Dis, Jan 2014., 2014 Jan shRNA TG310267
PPARD Exercise Training-Induced PPARβ Increases PGC-1α Protein Stability and Improves Insulin-Induced Glucose Uptake in Rodent Muscles Nutrients, 2020 Feb shRNA TG501712
PPARD PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise Cell Metab., 2017 May shRNA TF709733
PPARD Changes in PPARδ expression in a rat model of stress-induced depression Clin. Exp. Pharmacol. Physiol, 2017 Mar shRNA TR709733
Ppard Serine Carboxypeptidase SCPEP1 and Cathepsin A Play Complementary Roles in Regulation of Vasoconstriction via Inactivation of Endothelin-1 PLoS Genetics, 2014 Feb shRNA TF501712
Pparg Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell reports, 2019 Aug shRNA TF510219
PPARG Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung Biochem. Biophys. Res. Commun., 2017 Jul shRNA TG510219
PPARG Activation of peroxisome proliferator-activated receptor a stimulates ADAM10-mediated proteolysis of APP Proc. Natl. Acad. Sci. U.S.A., 2015 Jul shRNA TG320459
PPARG TGFß can stimulate the p(38)/ß-catenin/PPAR? signaling pathway to promote the EMT, invasion and migration of non-small cell lung cancer (H460 cells) Clin. Exp. Metastasis, 2014 Aug shRNA TR320459
PPARGC1A PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts Genet. Mol. Biol., 2020 Jul shRNA TG310260
PPARGC1A Genome-wide analyses of transcription factors and co-regulators across seven cohorts identified reduced PPARGC1A expression as a driver of prostate cancer progression bioRxiv, 2020 May shRNA TG310260
PPARGC1A Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7 Neuron, 2019 Dec shRNA TG310260
PPARGC1A c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer Mol Oncol, 2019 May shRNA TR310260
PPARGC1A PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis Nat. Cell Biol., 2014 Sep shRNA TG310260
Ppif Cyclophilin D-induced mitochondrial impairment confers axonal injury after intracerebral hemorrhage in mice Neural Regeneration Research, 2023 Apr shRNA TL713307
PPP1R12A Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness Mol. Cancer, 2020 Jan shRNA TR310238
PPP2CA Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model Br. J. Cancer, 2014 Mar shRNA TG310229
PPP2R1A Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors Mod. Pathol., 2016 Jul shRNA TR310227
PPP4R2 PATZ1 induces PP4R2 to form a negative feedback loop on IKK/NF-κB signaling in lung cancer Oncotarget, 2016 Aug shRNA TF302311
PRB1 Transcriptional Activation by pRB and Its Coordination with SWI/SNF Recruitment Cancer Res., Nov 2010; 70: 8282 - 8287, 2010 Nov shRNA TR310199
PRDX1 Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication Vaccine, 2018 Jul shRNA TG302287