shRNA Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
Rcan1 Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction Biochem. Pharmacol., 2017 Jul shRNA TR511392
RCAN1 RCAN1-4 is a thyroid cancer growth and metastasis suppressor JCI Insight, 2017 Mar shRNA TR304903
RCAN1 Pituitary adenylate cyclase-activating polypeptide (PACAP) targets Down syndrome candidate region 1 (DSCR1/RCAN1) to control neuronal differentiation J. Biol. Chem., 2015 Jul shRNA TG713231
RCAN1 APP facilitates the RCAN1-mediated apoptosis by downregulating PSMA5 and PSMB7 Neurobiology of Aging, 2014 Aug shRNA TF304903
RCAN1 The Regulator of Calcineurin 1 (RCAN1/DSCR1) Activates the cAMP Response Element-binding Protein (CREB) Pathway J. Biol. Chem., Oct 2011; 286: 37841 - 37848., 2011 Oct shRNA TR511392
REC8 REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells Oncol. Rep., 2018 Feb shRNA TG309883
REC8 REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype Oncogene, 2016 May shRNA TG309883
Rec8 The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells. Experimental cell research, 2009 Sep shRNA TL509475
RECQL4 Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis Cancer Res., Nov 2010; 70: 9207 - 9217, 2010 Nov shRNA TR309882
REG1A REG{gamma} deficiency promotes premature aging via the casein kinase 1 pathway PNAS, Jul 2013; 110: 11005 - 11010., 2013 Jul shRNA TG309878
REG4 REG{gamma} modulates p53 activity by regulating its cellular localization J. Cell Sci., Dec 2010; 123: 4076 - 4084, 2010 Dec shRNA TR302039
RELA Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons Molecular and Cellular Neuroscience, 2017 Feb shRNA TG713753
RELA NF-?B regulates neuronal ankyrin-G via a negative feedback loop Sci Rep, 2017 Feb shRNA TR516660
RELA COMMD7 is correlated with a novel NF-?B positive feedback loop in hepatocellular carcinoma Oncotarget, 2016 May shRNA TR302038
RELA Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ -secretase inhibitor, in a preclinical colorectal explant model British Journal of Cancer, 2013 Aug shRNA TF302038
RELA Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-{kappa}B Signaling Pathway Mol. Cancer Ther., Jan 2011; 10: 198 - 208, 2011 Jan shRNA TR302038
RELA Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis Physiol Genomics, Nov 2010; 42A: 259 - 266, 2010 Nov shRNA TR302038
RFC1 Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Jan 2013; 41: 855 - 868., 2013 Jan shRNA TG501877
RFC2 DNA damage response defect in Williams-Beuren syndrome Int. J. Mol. Med., 2017 Mar shRNA TG309864
RFC2 PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature, 2017 Jan shRNA TG309864
RFC2 DNA damage response defect in Williams‑Beuren syndrome INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2017 Jan shRNA TG309864
RFC4 Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Jan 2013; 41: 855 - 868., 2013 Jan shRNA TG505746
RFX1 RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells Carcinogenesis, 2014 Oct shRNA TG309857
RFX1 SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma Neoplasia July 2014, 2014 Jul shRNA TR309857
RGCC Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421, 2011 Jun shRNA TR315657
RGS4 Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response Biochem. Biophys. Res. Commun., 2016 Mar shRNA TG510988
RGS4 Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4 Cancer Res., Jul 2009; 69: 5743 - 5751., 2009 Jul shRNA TR309833
RHBDD1 Intramembrane protease RHBDL4 interacts with erlin complex to target unstable soluble proteins for degradation bioRxiv, 2019 Nov shRNA TR302010
RHBDF1 Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression EBioMedicine, 2018 Oct shRNA TR302009
RHBDF1 Human Rhomboid Family-1 (RHBDF1) Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1a in Breast Cancer Cancer Res., 2014 Mar shRNA TF302009
RHOA Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA2) signaling enhances cancer cell survival to cisplatin Biochemical and Biophysical Research Communications, 2020 Aug shRNA TG309823
RHOA S100A4 is activated by RhoA and catalyzes the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle J. Physiol. (Lond.) 2020, 2020 Aug shRNA TG309823
RHOC Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA2) signaling enhances cancer cell survival to cisplatin Biochemical and Biophysical Research Communications, 2020 Aug shRNA TG302002
RHOQ GTP Hydrolysis of TC10 Promotes Neurite Outgrowth through Exocytic Fusion of Rab11- and L1-Containing Vesicles by Releasing Exocyst Component Exo70 PLoS ONE e79689, 2013 Nov shRNA TF309817
RHOT1 Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy EMBO J., Feb 2014., 2014 Feb shRNA TG309816
RHOU The Transforming Rho Family GTPase Wrch-1 Disrupts Epithelial Cell Tight Junctions and Epithelial Morphogenesis Mol. Cell. Biol., Feb 2009; 29: 1035 - 1049., 2009 Feb shRNA TR307205
RICTOR Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary Mol. Cancer Ther., Jul 2013; 12: 1367 - 1377., 2013 Jul shRNA TG307650
Rif1 A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Molecular cell, 2013 Apr shRNA TF502862
RIOX2 Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion PLoS ONE, Feb 2014., 2014 Feb shRNA TF317654
RIPK1 RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy, 2015 May shRNA TG320591
RIPK1 RIP1 Kinase Is an Oncogenic Driver in Melanoma Cancer Res., 2015 Feb shRNA TG320591
RMDN3 Effectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells Oncogenesis, 2018 Aug shRNA TG304606
RNASEK A Subtle Alternative Splicing Event Gives Rise to a Widely Expressed Human RNase k Isoform PLoS ONE, 2014 May shRNA TR318608
RNF8 Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase for Degradation in Response to DNA Damage J. Biol. Chem., Feb 2013; 288: 2941 - 2950., 2013 Feb shRNA TG309783
RNH1 Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells Thesis Jul 2014, 2013 Jul shRNA TG309781
RNH1 RNH1 regulation of reactive oxygen species contributes to histone deacetylase inhibitor resistance in gastric cancer cells Oncogene doi:10.1038/onc.2013.104, 2013 Apr shRNA TG309781
ROCK1 Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE, 2015 Aug shRNA TG309775
ROR2 Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma Oncogene (18 May 2009) doi:10.1038/onc.2009.116 Original Article, 2009 May shRNA TR320439
RORA Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting Beta-catenin and AKT signaling but frequently methylated in common carcinomas Cell Mol Life Sci. 2013 Oct 25, 2013 Oct shRNA TR320515
RPA1 ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress Cell July 2014, 2014 Jul shRNA TR309767