siRNA Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
AKT2 miR-608 regulates apoptosis in human lung adenocarcinoma via regulation of AKT2 Int. J. Oncol., 2017 Oct siRNA SR300144
AKT2 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res., 2015 Dec siRNA SR300144
AKT2 Curcumin Modulates MicroRNA-203–Mediated Regulation of the Src-Akt Axis in Bladder Cancer Cancer Prevention Research, Oct 2011; 4: 1698 - 1709., 2011 Oct siRNA SR300144
AKT3 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res., 2015 Dec siRNA SR306727
ALDH18A1 Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma Clin. Cancer Res.2017, 2017 Oct siRNA SR303932
ALDH2 ALDH2 Activity Reduces Mitochondrial Oxygen Reserve Capacity in Endothelial Cells and Induces Senescence Properties Oxidative Medicine and Cellular Longevity, 2018 Nov siRNA SR319314
ALK Targeting ALK in pediatric RMS does not induce antitumor activity in vivo Cancer Chemother. Pharmacol., 2018 May siRNA SR300165
ALK Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma Clin. Cancer Res., 2017 Jun siRNA SR300165
ALOX12 Arachidonate 12-Lipoxygenase and 12-Hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer J. Biol. Chem., 2020 Apr siRNA SR300166
ALOX12E STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection J. Exp. Med., 2018 Feb siRNA SR41884
ALOX15 Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution Cell Rep, 2020 Oct siRNA SR300171
ANGPT1 NEAT1 promotes the repair of abdominal aortic aneurysms of endothelial progenitor cells via regulating miR-204-5p/Ang-1 American journal of translational research, 2021 Apr siRNA SR512502
ANGPT2 Angiopoietin-2 secretion by endothelial cells exosome: regulation by the PI3K/Akt/eNOS and syndecan 4/syntenin pathways J. Biol. Chem., 2013 Nov siRNA SR300199
Ano1 Arctigenin Attenuates Vascular Inflammation Induced by High Salt through TMEM16A/ESM1/VCAM-1 Pathway Biomedicines, 2022 Oct siRNA SR411408
ANO1 Knockdown of TMEM16A suppressed MAPK and inhibited cell proliferation and migration in hepatocellular carcinoma OncoTargets and therapy, 2016 Jan siRNA SR310492
ANXA2 Annexin A2 Mediates Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Binding to Eukaryotic Cells MBio, 2014 Aug siRNA SR300208
APC A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions. Cell calcium, 2014 Mar siRNA SR300226
APEX1 AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy Oncotarget, 2016 Jun siRNA SR300230
APLP2 Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9 convertase-mediated low density lipoprotein receptor degradation but interact with each other J. Biol. Chem., 2015 Jun siRNA SR300236
AQP3 AQP3-Dependent PI3K/Akt Modulation in Breast Cancer Cells. International journal of molecular sciences, 2023 Jun siRNA SR300258
AQP3 AQP3 Increases Intercellular Cohesion in NSCLC A549 Cell Spheroids through Exploratory Cell Protrusions International Journal of Molecular Sciences, 2021 Apr siRNA SR300258
AR c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer Oncotarget, 2016 Nov siRNA SR300264
Areg ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion JCI Insight, 2022 Sep siRNA SR406992
ARF6 EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth Nat Commun, 2017 Mar siRNA SR300275
ARG2 Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase Cell Rep, 2019 Feb siRNA SR319383
ARG2 Human cytomegalovirus may promote tumour progression by upregulating arginase-2 Oncotarget, 2016 Jul siRNA SR300277
ARHGDIA Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity Journal of Cell Communication and Signaling, 2022 Nov siRNA SR300287
ARHGEF39 ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients Lab. Invest., 2018 Jan siRNA SR313727
ARID1A Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway Virchows Arch., 2020 Aug siRNA SR305421
ARID1A Downregulation of ARID1A, a component of the SWI/SNF chromatin remodeling complex, in breast cancer Journal of Cancer, 2017 Jan siRNA SR305421
ARID2 Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer J. Mol. Med., 2016 Feb siRNA SR316272
Arl8b α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes PLoS Biology, 2021 Jul siRNA SR404583
ARNT Hypoxia-inducible factor-1 promotes cancer progression through activating AKT/Cyclin D1 signaling pathway in osteosarcoma Biomed. Pharmacother., 2018 May siRNA SR300295
ARNT Defining the role of oxygen tension in human neural progenitor fate Stem Cell Reports, 2014 Nov siRNA SR300295
ARNT Hypoxia Inducible Regulation of Placental BOK Expression Biochem. J., 2014 May siRNA SR300295
ARPC5L Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine Leukemia, 2014 Mar siRNA SR313117
ASAH1 Acid Ceramidase in Melanoma: Expression, Localization and Effects of Pharmacological Inhibition J. Biol. Chem., 2015 Nov siRNA SR300310
ASNS Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL Clin. Cancer Res., 2019 Jan siRNA SR300319
ASNS Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells Scand. J. Gastroenterol., 2016 Jun siRNA SR300319
ASS1 Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI-PEG20 treatment in CCA cell lines Oncol Lett, 2018 Aug siRNA SR300322
ASS1 Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI‑PEG20 treatment in CCA cell lines Oncol Lett, 2018 May siRNA SR300322
ATF2 A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells, 2014 Aug siRNA SR300975
ATF4 Tetracyclines promote survival and fitness in mitochondrial disease models Nature metabolism, 2021 Jan siRNA SR319410
ATF4 GCN2 reduces inflammation by p-eIF2α/ATF4 pathway after intracerebral hemorrhage in mice Exp. Neurol., 2018 Dec siRNA SR411790
ATF5 A cytosolic surveillance mechanism activates the mitochondrial UPR Nature, 2023 Jun siRNA SR307793
ATF6 A miR-494 dependent feedback loop regulates ER stress bioRxiv, 2020 May siRNA SR307883
ATF6 The role of ORMDL3/ATF6 in compensated beta cell proliferation during early diabetes Aging (Albany NY) 2019, 2019 May siRNA SR418766
ATF6 Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells J. Cell. Physiol., 2018 Aug siRNA SR323457
ATF6 Alkylating agent induced NRF2 blocks endoplasmic reticulum stress-mediated apoptosis via control of glutathione pools and protein thiol homeostasis Mol. Cancer Ther., 2016 Sep siRNA SR307883
ATF6 Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis Respir. Res. Dec 2013., 2013 Dec siRNA SR418766