shRNA Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
UHMK1 Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene Bone, 2016 Jul shRNA TR320754
UHRF1 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus J. Clin. Invest., 2016 Feb shRNA TG308492
UNC13B CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis Mol. Biol. Cell Dec 2013., 2013 Dec shRNA TG710861
Unc93b1 Antioxidative properties of paraoxonase 2 in intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, Sep 2012; 303: G623 - G634., 2012 Sep shRNA TR515293
UPF1 UPF1 silenced cellular model systems for screening of read-through agents active on β039 thalassemia point mutation BMC Biotechnol., 2018 May shRNA TR308482
UPF1 Modulation of nonsense mediated decay by rapamycin Nucleic Acids Res., 2016 Nov shRNA TR308482
UPF1 A luciferase reporter assay to investigate the differential selenium-dependent stability of selenoprotein mRNAs. The Journal of nutritional biochemistry, 2013 Feb shRNA TR308482
USP17L2 The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression Cancer Res., Apr 2010; 70: 3329 - 3339, 2010 Apr shRNA TR307933
USP17L9P The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility Nature Communications 2, 259 (29 March 2011) doi:10.1038/ncomms1243 Article, 2011 Mar shRNA TR321147
USP17L9P The Deubiquitinating Enzyme USP17 Blocks N-Ras Membrane Trafficking and Activation but Leaves K-Ras Unaffected J. Biol. Chem., Apr 2010; 285: 12028 - 12036, 2010 Apr shRNA TR321147
USP19 USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer OncoTargets and therapy, 2020 Aug shRNA TR308463
Usp21 Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions Mol. Biol. Cell, Mar 2012; 23: 1095 - 1103., 2012 Mar shRNA TR708469
USP4 Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease Hepatology, 2018 Mar shRNA TG502380
USP7 Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation The Journal of Biological Chemistry, 2022 Feb shRNA TL308454
USP7 USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway Proc Natl Acad Sci U S A, 2020 Oct shRNA TF308454
USP7 HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation Nucleic Acids Res. April 2014, 2014 Apr shRNA TR308454
USP8 USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels J. Neurosci., 2018 May shRNA TG705081
USP9X TGFβ-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Maintenance SSRN Journal, 2020 Jan shRNA TF510959
USP9X TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance Cell Rep, 2020 Jan shRNA TF510959
UXT Depletion of UXT, a novel TSG101 interaction protein, leads to enhanced CEP55 attenuation through lysosome degradation Biochemical and biophysical research communications, 2021 Jan shRNA TF308443
VAMP2 The SNARE Proteins SNAP25 and Synaptobrevin Are Involved in Endocytosis at Hippocampal Synapses J. Neurosci., May 2013; 33: 9169 - 9175., 2013 May shRNA TF709295
VAMP3 The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling TCRs to the immune synapse J. Cell. Sci., 2015 Jun shRNA TR308442
VAMP3 The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling TCRs to the immune synapse J. Cell. Sci., 2015 Jun shRNA TR515358
VAMP3 Regulated delivery of molecular cargo to invasive tumour-derived microvesicles Nat Commun, 2015 Apr shRNA TF308442
various knockdown plasmids NF-B regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes Nucleic Acids Res., Jan 2012; 40: 181 - 195., 2012 Jan shRNA
Vash1 Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Science (New York, N.Y.), 2018 Jan shRNA TL511800
Vash2 Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Science (New York, N.Y.), 2018 Jan shRNA TL506751
Vav2 Transcription factor CUX1 is required for intestinal epithelial wound healing and targets the VAV2-RAC1 Signalling complex. Biochimica et biophysica acta. Molecular cell research, 2018 Feb shRNA TL705141
VCAN Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids J Ovarian Res July 2014, 2014 Jul shRNA TG313695
Vdr The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo The Journal of Physiology, 2020 Dec shRNA TL709870
VDR RNAi-mediated knockdown of VDR surprisingly suppresses cell growth in Jurkat T and U87-MG cells Heliyon, 2019 Nov shRNA TG320568
VDR Vitamin D deficiency in rats causes cardiac dysfunction by inducing myocardial insulin resistance Mol Nutr Food Res, 2019 May shRNA TG513148
VDR Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis Gut July 2014, 2014 Jul shRNA TG320568
Vegfa Fluid Flow-induced Soluble Vascular Endothelial Growth Factor Isoforms Regulate Actin Adaptation in Osteoblasts J. Biol. Chem., Oct 2010; 285: 30931 - 30941, 2010 Oct shRNA TR510369
VENTX VentX trans-Activates p53 and p16ink4a to Regulate Cellular Senescence J. Biol. Chem., Apr 2011; 286: 12693 - 12701, 2011 Apr shRNA
VENTX VentX, a Novel Lymphoid-Enhancing Factor/T-Cell Factor–Associated Transcription Repressor, Is a Putative Tumor Suppressor Cancer Res., Jan 2010; 70: 202 - 211, 2010 Jan shRNA TR317112
VHL Oncotropic H-1 parvovirus infection degrades HIF-1a protein in human pancreatic cancer cells independently of VHL and RACK1 Int. J. Oncol., 2015 May shRNA TR300577
VPS13A A conserved function in phosphatidylinositol metabolism for Mammalian vps13 family proteins PLoS ONE, 2015 Apr shRNA TF704233
Vps35 Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer’s disease Neuron, 2014 Sep shRNA TL503494
WDR5 TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis Cancer Res., 2017 May shRNA TG300500
WDR5 TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis Cancer Res., 2017 May shRNA TG513026
WDR5 WDR5 high expression and its effect on tumorigenesis in leukemia Oncotarget, 2016 May shRNA TG300500
WDR82 Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cells bioRxiv, 2020 Jan shRNA TG301034
WEE1 Whole-Genome Expression Microarray Combined with Machine Learning to Identify Prognostic Biomarkers for High-Grade Glioma J. Mol. Neurosci., 2018 Mar shRNA TF320571
WFDC2 Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6 Front Pharmacol, 2019 Mar shRNA TR318721
WFDC2 HE4 sabotages cytotoxic mononuclear cells via inducing dual specificity phosphatase 6 secretion Gynecologic Oncology, 2018 Jun shRNA TR318721
WFDC2 HE4 suppresses the expression of osteopontin in mononuclear cells and compromises their cytotoxicity against ovarian cancer cells Clin. Exp. Immunol., 2018 May shRNA TR318721
WIF1 Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3 Int. J. Cancer, 2018 Jul shRNA TG513512
Wnk1 WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science signaling, 2016 Mar shRNA TL712155
WNK3 With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume Am J Physiol Cell Physiol, Nov 2011; 301: C1150 - C1160., 2011 Nov shRNA TR320730