shRNA Citations

OriGene products have been used extensively by scientists worldwide to improve their research efficiency. For your reference, we have collected a representation of citations for selected OriGene products and posted them at this site.

Search citations by gene symbols or target names

Here are some of the recent papers making use of OriGene products by fellow researchers.

Target Research Paper Journal Product SKU
WNT3A Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3 Int. J. Cancer, 2018 Jul shRNA TG300447
Wnt3a Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/ß-catenin pathway Neuro Oncology, Jul 2013; 10.1093/neuonc/not104., 2013 Jul shRNA TG300447
WNT4 Context dependent non canonical WNT signaling mediates activation of fibroblasts by transforming growth factor-ß Exp. Cell Res., 2015 Mar shRNA TG300446
WNT5A Activation of Wnt5A signaling is required for CXC chemokine ligand 12–mediated T-cell migration Blood, Aug 2009; 114: 1366 - 1373, 2009 Aug shRNA TR320572
WNT5A Activation of Wnt5A signaling is required for CXCL12-mediated T-cell migration Blood, Jun 2009; 10.1182/blood-2008-08-175869, 2009 Jun shRNA TR320572
WNT5B Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras–Mutated Colorectal Cancer Mol. Cancer Ther., Dec 2010; 9: 3351 - 3362, 2010 Dec shRNA TR300445
WNT6 WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma Theranostics, 2018 Sep shRNA TR308360
WRN CDK1 phosphorylates WRN at collapsed replication forks Nat Commun, 2016 Sep shRNA TR308355
WRN Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress Nucleic Acids Res., 2014 Oct shRNA TF308355
WRNIP1 Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability Cancers (Basel) 2020, 2020 Feb shRNA TR300444
WRNIP1 Checkpoint defects require WRNIP1 to counteract R-loop-associated genomic instability bioRxiv, 2019 Nov shRNA TR300444
WT1 Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis FASEB J., 2013 Nov shRNA TG300442
Wwp2 DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells Stem Cell Reports, 2017 Mar shRNA TG516592
WWTR1 Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in the muscle injury model Mol. Cell. Biol., Feb 2014., 2014 Feb shRNA TF505533
XIAP MicroRNA-212 inhibits the proliferation, migration and invasion of renal cell carcinoma by targeting X-linked inhibitor of apoptosis protein (XIAP) Oncotarget, 2017 Nov shRNA TG314473
XKR5 XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation Oncogenesis, 2018 Jun shRNA TG300427
XPA Downregulated XPA promotes carcinogenesis of bladder cancer via impairment of DNA repair Tumour Biol, 2017 Feb shRNA TR308346
XPC The Xpc gene markedly affects cell survival in mouse bone marrow Mutagenesis, Jul 2009; 24: 309 - 316., 2009 Jul shRNA TR308345
XRCC3 WRN controls formation of extrachromosomal telomeric circles and is required for TRF2B-mediated telomere shortening Mol. Cell. Biol., Mar 2008; 28: 1892 - 1904., 2008 Mar shRNA TR510156
XRCC5 Dual Functions of the Homeoprotein DLX4 in Modulating Responsiveness of Tumor Cells to Topoisomerase II-Targeting Drugs Cancer Res., Jan 2013; 73: 1000 - 1010., 2013 Jan shRNA TG300421
YAP1 Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway Biosci. Rep., 2020 Mar shRNA TR308332
YAP1 YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression J. Exp. Clin. Cancer Res., 2020 Feb shRNA TG502437
YBX1 Silencing Y-box binding protein-1 inhibits triple-negative breast cancer cell invasiveness via regulation of MMP1 and beta-catenin expression Cancer Lett., 2019 Mar shRNA TG308329
YWHAB Infection of Prions and Treatment of PrP106-126 Alter the Endogenous Status of Protein 14-3-3 and Trigger the Mitochondrial Apoptosis Possibly via Activating Bax Pathway Mol Neurobiol. 2013 Oct 18, 2013 Oct shRNA TG300398
Yy1 An integrated transcriptomics-guided genome-wide promoter analysis and next-generation proteomics approach to mine factor(s) regulating cellular differentiation DNA Res, 2017 Jan shRNA TR713377
ZBTB10 MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells Endocrinology, Jun 2010; 151: 2462 - 2473, 2010 Jun shRNA TR300388
Zbtb16 Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice International Neurourology Journal, 2022 Nov shRNA TL507125
ZDHHC18 DHHC protein family targets different subsets of glioma stem cells in specific niches J. Exp. Clin. Cancer Res., 2019 Jan shRNA TF307371
Zdhhc3 Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons The Journal of Biological Chemistry, 2023 Jun shRNA TL703601
Zdhhc3 Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a Nat Commun, 2017 Dec shRNA TG504254
ZDHHC8 Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome Cereb. Cortex, 2016 Jun shRNA TF308290
Zeb1 Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2 Cellular and Molecular Gastroenterology and Hepatology, 2022 Jul shRNA TL513177
ZEB1 CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells International journal of molecular sciences, 2021 Jan shRNA TR301174
Zeb1 CXCR2+ MDSCs promote breast cancer progression by inducing EMT and activated T cell exhaustion Oncotarget, 2017 Dec shRNA TG513177
ZEB1 Ginkgolide B Inhibits Human Bladder Cancer Cell Migration and Invasion Through MicroRNA-223-3p Cell. Physiol. Biochem., 2016 Nov shRNA TR301174
ZEB2 miR-637 Prevents Glioblastoma Progression by Interrupting ZEB2/WNT/β-catenin Cascades. Cellular and molecular neurobiology, 2022 Aug shRNA TG308288
ZEB2 miR-637 prevents glioblastoma progression by interrupting ZEB2/WNT/β-catenin cascades Research Square, 2021 Mar shRNA TG308288
Zfp423 Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation Molecular and Cellular Biology, 2019 Jan shRNA TL711983
Zfp521 Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch Molecular and Cellular Biology, 2014 Aug shRNA TL705963
Zfp521 Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch Mol. Cell. Biol., 2014 Aug shRNA TG506694
Zfpm2 ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism J. Clin. Invest. April 2014, 2014 Apr shRNA TG512097
ZNF567 RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy, 2015 May shRNA TG300130
ZNF567 RIP1 Kinase Is an Oncogenic Driver in Melanoma Cancer Res., 2015 Feb shRNA TG300130
ZSCAN4 ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype Oncogene, 2020 Jun shRNA TF300013
ZSCAN5A A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target Transl Oncol, 2017 May shRNA TR300012
ZSCAN5A The Transcriptional Activity of Osterix Requires the Recruitment of Sp1 to the Osteocalcin Proximal Promoter Bone, 2012 Oct shRNA TR300012