RAF1 Mouse Monoclonal Antibody [Clone ID: PBB-1]

CAT#: AM00132PU-N

RAF1 mouse monoclonal antibody, clone PBB-1, Purified


USD 415.00

2 Weeks*

Size
    • 100 ug

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Specifications

Product Data
Clone Name PBB-1
Applications WB
Recommended Dilution Western Blot: 0.5 µg/ml for HRPO/ECL detection.
Recommended blocking buffer: Casein/Tween 20 based blocking and blot incubation buffer.
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen c-Raf kinase domain.
Specificity This antibody specifically recognizes c-raf in Western blot applications.
Formulation PBS/0.09% Sodium Azide/PEG and Sucrose/50% Glycerol
State: Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Subsequent Thiophilic Adsorption and Size Exclusion Chromatography
Storage Store the antibody (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1)
Background The c-raf protein is an important kinase in the transmission of extracellular stimuli to the nucleus. Mitogenic stimulaton of cells induces hyperphosphorylation of c-raf in multiple serine, threonine and tyrosine residues. Phosphorylation of serines 43, 259 and 621 has been implicated in the negative regulation of raf. Phosphorylation of serine 43 interferes with ras binding, serine 259 and serine 621 represent binding sites for the 14-3-3 proteins.
Synonyms C-RAF, Raf-1, cRaf
Note Mol. Weight: 74 kDa
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Acute myeloid leukemia, B cell receptor signaling pathway, Bladder cancer, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.