Ki67 (MKI67) Mouse Monoclonal Antibody [Clone ID: Ki-67]
Specifications
Product Data | |
Clone Name | Ki-67 |
Applications | FC, IF |
Recommended Dilution | Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. |
Reactivities | Bovine, Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Nuclei of the Hodgkin lymphoma cell line L428 |
Specificity | This antibody recognizes Ki-67 antigen, a non-histone nuclear protein expressed exclusively in proliferating cells. |
Formulation | Phosphate buffered saline (PBS) Label: PE State: Liquid purified Ig fraction Preservative: 15 mM sodium azide Label: Conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. |
Conjugation | PE |
Storage | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | Ki-67 is a highly protease-sensitive nuclear protein expressed in two isoforms (345 kDa and 395 kDa), both of which are identified by the antibody clone Ki-67. The Ki-67 antigen is essential for cell proliferation and its expression is restricted to the cycling cells. It is detected in G1, S, G2 and M phase, whereas it is absent in cells which are in G0 phase and it is not associated with DNA repair processes. Ki-67 thus represents an important tool for detection of proliferating cells, which is of great importance in tumor diagnostics and is commonly used as a prognostic factor in cancer studies. |
Synonyms | Ki67 antigen, MKI67, Proliferation marker |
Reference Data |
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