FK506 Mouse Monoclonal Antibody [Clone ID: FK1]
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Specifications
Product Data | |
Clone Name | FK1 |
Applications | ELISA |
Recommended Dilution | ELISA. |
Host | Mouse |
Isotype | IgM |
Clonality | Monoclonal |
Immunogen | FK-506-BSA conjugate. Spleen cells from immunised Balb/c mice were fused with cells of the Sp2/0 myeloma cell line. |
Specificity | This antibody clone FK1 detects FK-506, a macrolide with similar but more potent immunosuppressant activity than cyclosporine. |
Formulation | TRIS buffered saline, pH 8.0 State: Purified State: Liquid purified IgM fraction Preservative: 0.09% Sodium Azide |
Concentration | 1.0 mg/ml |
Background | FK-506 is a 23-membered lactone produced by the bacteria Streptomyces tsukubaensis. FK-506 inhibits signal transduction and interleukin-2 transcription in CD4+ T helper lymphocytes, and is mainly used after allogenic organ transplantation to reduce organ rejection. Side effects of FK-506 treatment include nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension. |
Synonyms | Tacrolimus, FK-506 |
Reference Data |
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