DcR1 (TNFRSF10C) Mouse Monoclonal Antibody [Clone ID: TRAIL-R3-02]

CAT#: AM03038FC-N

DcR1 (TNFRSF10C) mouse monoclonal antibody, clone TRAIL-R3-02, FITC

Specifications

Product Data

• Clone Name: TRAIL-R3-02
• Applications: FC
• Recommended Dilution: Flow Cytometry: 3 µg/ml.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: TRAIL-R3 (aa 1-280) - hIgGhc fusion protein.
• Specificity: The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
• Formulation: PBS containing 15 mM Sdium Azide as preservative and 0.2% (w/v) high-grade (Protease free) BSA as a stabilizing agent.
  Label: FITC
  State: Liquid purified IgG fraction.
  Label: Fluorescein Isothiocyanate Isomer 1
• Concentration: 0.1 mg/ml
• Conjugation: FITC
• Gene Name: Homo sapiens tumor necrosis factor receptor superfamily member 10c (TNFRSF10C)
• Database Link:
  Entrez Gene 8794 Human
• Background: TRAIL-R3 (CD263, TR3, DcR1, LIT, TRID), expressed mainly on neutrophils, belongs to receptors of TRAIL, a TNF-like membrane cytotoxic protein that induces apoptosis in many tumour cells, but not in normal cells. TRAIL-R3, however, is a GPI-anchored protein that lacks cytoplasmic death domain, thus it is unable to induce apoptosis and serves as a negative regulator of apoptotic signaling by competing for binding of TRAIL with death receptor 5 (DR5).
• Synonyms: Decoy receptor 1, TNFRSF10C, DCR1, LIT, TRID, TRAIL receptor 3, TRAIL-R3

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity