CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: MEM-229]

CAT#: AM03092BT-N

CD105 (ENG) mouse monoclonal antibody, clone MEM-229, Biotin


USD 270.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name MEM-229
Applications FC, IF
Recommended Dilution Indirect immunofluorescence analysis by Flow Cytometry.
Reactivities Human, Porcine
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA.
Specificity This antibody recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Formulation PBS, pH~7.4
Label: Biotin
State: Liquid purified Ig fraction
Preservative: 15 mM Sodium Azide
Label: Conjugated with -LC-NHS under optimum conditions. The reagent is free of unconjugated biotin
Concentration lot specific
Conjugation Biotin
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens endoglin (ENG), transcript variant 2
Background CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Synonyms ENG, END, HHT1, ORW, ORW1
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.