CD51 / ITGAV Rat Monoclonal Antibody [Clone ID: RMV-7]

CAT#: AM05569LE-N

CD51 / ITGAV rat monoclonal antibody, clone RMV-7, Low Endotoxin

Specifications

Product Data

• Clone Name: RMV-7
• Applications: FC, FN, IP
• Recommended Dilution: Flow Cytometry: 1/10 - 1/100.
  Immunoprecipitation.
  Functional Assays.
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: cultured LAK cells from Balb/c mice.
• Specificity: This antibody recognises CD51. The RMV-7 antibody has been reported to block binding of CD51 to vitronectin, fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity.
• Formulation: Phosphate buffered saline pH7.4
  State: Low Endotoxin
  State: Liquid purified IgG
• Concentration: 1.0mg/ml
• Purification: Affinity chromatography on Protein G
• Background: CD51 is a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the intergrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 functions as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing.
• Synonyms: Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha