ErbB 3 (ERBB3) Mouse Monoclonal Antibody [Clone ID: 3F10F6]
Specifications
Product Data | |
Clone Name | 3F10F6 |
Applications | IHC, WB |
Recommended Dilution | ELISA: 1/10000. Western Bloting: 1/500 - 1/2000. Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Purified recombinant fragment of ERBB3 (aa1175-1275) expressed in E. Coli. |
Specificity | Recognizes ERBB3 |
Formulation | State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide. |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. |
Synonyms | ERBB-3, c-erbB-3, HER-3 |
Reference Data |
Documents
Product Manuals |
FAQs |
{0} Product Review(s)
0 Product Review(s)
Submit review
Be the first one to submit a review
Product Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.