Cd2 Rat Monoclonal Antibody [Clone ID: 12-15]

CAT#: AM08025PU-N

Cd2 rat monoclonal antibody, clone 12-15, Purified

Specifications

Product Data

• Clone Name: 12-15
• Applications: FC, FN, IP
• Recommended Dilution: Flow Cytometry (Ref.1-3)
  Immunoprecipitation. (Ref.1-2)
  Functional Assay:
  In vitro Inhibition of CTL-mediated lysis. (Ref.1)
  Induction of T cell unresponsiveness in vivo. (Ref.4)
• Reactivities: Mouse
• Host: Rat
• Isotype: IgG1
• Clonality: Monoclonal
• Specificity: This antibody is specific to CD2/LFA-2 (Mr 45-58 kDa)
• Formulation: 100 mM Borate Buffered Saline, pH 8.2.
  No preservatives or amine-containing buffer salts added.
  State: Purified
  State: Liquid purified Ig fraction.
• Concentration: 0.5 mg/ml
• Database Link:
  Entrez Gene 12481 Mouse
• Background: CD2, also known as leukocyte function-associated antigen-2 (LFA-2), is a member of the immunoglobulin superfamily of cell adhesion molecules. (Ref.1) It is expressed on the surface of >95% of thymocytes, and essentially all B cells, T cells and NK cells. (Ref.1-3) In the mouse, CD2 is the receptor for CD48. (Ref.4) CD2 is thought to play a major role in mediating T-cell adhesion, T-cell recognition/activation, T-cell signaling and intrathymic differentiation. (Ref.5-10)
• Synonyms: SRBC, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor