Cd80 Rat Monoclonal Antibody [Clone ID: 1G10]

CAT#: AM08052LE-N

Cd80 rat monoclonal antibody, clone 1G10, Low Endotoxin


USD 370.00

3 Days*

Size
    • 500 ug

Product Images

Specifications

Product Data
Clone Name 1G10
Applications FC, FN, IP
Recommended Dilution Flow Cytometry. (Ref.2,7)
Immunoprecipitation. (Ref.7)
Functional Assays: In vivo and In vitro blocking of ligand binding. (Ref.7)
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Specificity This antibody recognises CD80/B7-1 (Mr. 45-47 kDa).
1G10 blocks binding of CTLA-4 to CD80, but it does not block stimulation of T cells by natural antigenpresenting cells. (Ref.2,7).
Formulation PBS without preservatives.
State: Low Endotoxin
State: Liquid purified Ig fraction.
Concentration 0.5 mg/ml
Background CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines.
Synonyms CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.