FPRL1 (FPR2) (C-term) Mouse Monoclonal Antibody [Clone ID: B4D9B10]

CAT#: AM09318PU-N

FPRL1 (FPR2) (C-term) mouse monoclonal antibody, clone B4D9B10, Purified

Product Images

Figure 1. Western blot analysis of extracts from HL60 cells using anti-FPRL1 antibody (clone B4D9B10) at 1 ug/ml.

Specifications

Product Data

• Clone Name: B4D9B10
• Applications: ELISA, WB
• Recommended Dilution: ELISA: Reactive to the C-terminal amino acid sequence (SASPPAETELQAM) on FPRL1 in Indirect ELISA.
  Western Blot (1/1000).
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: A short peptide corresponding to the Cterminal amino acid sequence (SASPPAETELQAM) on FPRL1
• Specificity: This monoclonal antibody reacts with the above mentioned peptide in ELISA and reacts with the 38KDa FPRL1 on Western Blot.
• Formulation: 0.01M PBS, pH 7.2 without preservatives
  State: Purified
  State: Lyophilized purified IgG fraction
• Reconstitution Method: Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml
• Purification: Affinity Chromatography
• Conjugation: Unconjugated
• Storage: Upon receipt, store (in aliquots) at -20°C.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens formyl peptide receptor 2 (FPR2), transcript variant 2
• Database Link:
  Entrez Gene 2358 Human
  UniProt ID P25090
• Background: FPRL1 is a low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries.
• Synonyms: N-formyl peptide receptor 2, FMLP-R-I, FPRH1, RFP, LXA4R

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction