MUC16 Rabbit Monoclonal Antibody [Clone ID: EPR1020(2)]

CAT#: AM10052SU-N

MUC16 rabbit monoclonal antibody, clone EPR1020(2), Purified

Product Images

Formalin-Fixed, Paraffin-Embedded Human ovarian carcinoma stained with CA125 antibody Cat.-No. AM10052SU-N using peroxidase conjugate and DAB chromogen. Note cell membrane staining of tumor cells.

Specifications

Product Data

• Clone Name: EPR1020(2)
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/40-1/100
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Ovarian carcinoma.
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthetic peptide corresponding to residues in Human CA125
• Specificity: This antibody recognizes Mucin-16/CA125.
  Cellular Localization: Extracellular memberane-associated.
• Formulation: State: Purified
  State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
• Gene Name: Homo sapiens B-cell CLL/lymphoma 6 (BCL6), transcript variant 2
• Database Link:
  Entrez Gene 94025 Human
• Background: As CA125 (Ovarian Cancer Antigen) is a tumor marker usually associated with ovarian epithelial malignancies. Serum assays are widely used to detect this protein in the monitoring of ovarian cancers. However, CA125 antigen may also be detected by immunohistochemistry and expression has been found in neoplasms such as seminal vesicle carcinoma and anaplastic lymphoma. CA125 antigen is not exclusively found in malignant tumors.
• Synonyms: MUC16, MUC-16, CA-125, CA 125

Reference Data

• Protein Families: Druggable Genome, Transcription Factors