Fascin (FSCN1) Mouse Monoclonal Antibody [Clone ID: 55K-2]

CAT#: AM10085SU-N

Fascin (FSCN1) mouse monoclonal antibody, clone 55K-2, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human Hodgkin’s lymphoma stained with Fascin antibody Cat.-No. AM10085SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of Hodgkin's cells.

Specifications

Product Data

• Clone Name: 55K-2
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/250
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Hodgkin’s lymphoma or spleen.
• Reactivities: Human, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Fascin purified from HeLa cells.
• Specificity: Clone 55K-2 can be used as an effective marker for Reed Sternberg cells.
  Cellular Localization: Cytoplasmic.
• Formulation: State: Supernatant
  State: Tissue Culture Supernant with 0.2% BSA and 15mM Sodium Azide.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1
• Database Link:
  Entrez Gene 24329 RatEntrez Gene 6624 Human
• Background: Human fascin is a highly conserved actin-bundling protein. Fascin, encoded by the human homolog for sn (hsn) gene, has been localized to microspikes and stress fibers of cultured cells where it is thought to be involved in the formation of microfilament bundles. It is expressed predominantly in dendritic cells. Lymphoid cells, myeloid cells and plasma cells are negative. However, Reed Sternberg cells in Hodgkin’s lymphoma are positive for fascin staining. Epstein-Barr virus may induce expression of fascin in B cells.
• Synonyms: SCN1, FAN1, HSN, SNL, p55, Singed-like protein, Dendritic cell marker

Reference Data

• Protein Families: Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Secreted Protein, Stem cell relevant signaling - JAK/STAT signaling pathway, Transmembrane
• Protein Pathways: Adherens junction, Bladder cancer, Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Dorso-ventral axis formation, Endocytosis, Endometrial cancer, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, GnRH signaling pathway, MAPK signaling pathway, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton