MLH1 Mouse Monoclonal Antibody [Clone ID: G168-728]

CAT#: AM10114SU-N

MLH1 mouse monoclonal antibody, clone G168-728, Supernatant


USD 715.00

5 Days*

Size
    • 1 ml

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Specifications

Product Data
Clone Name G168-728
Applications IHC
Recommended Dilution Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/100
Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
Use Polymer anti Mouse/Rabbit IgG as a detection system.
Positive Control: Colon carcinoma.
Reactivities Hamster, Human, Mouse, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Recombinant full length MLH protein.
Specificity The G168-15 antibody recognizes the Human and Mouse MLH1 (80-85kDa).
Cellular Localization: Nuclear.
Formulation State: Supernatant
State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
Storage Store the antibody undiluted at 2-8°C.
Stability Shelf life: one year from despatch.
Gene Name Homo sapiens microphthalmia-associated transcription factor (MITF), transcript variant 4
Background The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair.
Synonyms DNA mismatch repair protein Mlh1, COCA2
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Melanogenesis, Melanoma, Pathways in cancer

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.