EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: MRQ-17]

CAT#: AM10117SU-N

EMA (MUC1) mouse monoclonal antibody, clone MRQ-17, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human breast carcinoma stained with MUC1 antibody Cat.-No. AM10117SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of tumor cells.

Specifications

Product Data

• Clone Name: MRQ-17
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/100
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Breast carcinoma.
• Reactivities: Human, Mouse
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: A synthetic peptide from cytoplasmic tail of Human MUC-1 protein.
• Specificity: Recognizes CD227 / Mucin-1 / MUC1.
  Cellular Localization: Cytoplasmic.
• Formulation: State: Supernatant
  State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens microphthalmia-associated transcription factor (MITF), transcript variant 4
• Database Link:
  Entrez Gene 17342 MouseEntrez Gene 4582 Human
• Background: MUC-1 is a heavily O-glycosylated transmembrane protein expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC-1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.
• Synonyms: MUC-1, PEMT, Episialin, EMA, H23AG, PUM, DF3, CA 15-3

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Melanogenesis, Melanoma, Pathways in cancer