Mucin 5AC (MUC5AC) Mouse Monoclonal Antibody [Clone ID: MRQ-19]

CAT#: AM10119SU-N

Mucin 5AC (MUC5AC) mouse monoclonal antibody, clone MRQ-19, Supernatant

Product Images

Formalin-Fixed, Paraffin-Embedded Human pancreatic ductal carcinoma stained with Mucin-5AC antibody Cat.-No. AM10119SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of tumor cells.

Specifications

Product Data

• Clone Name: MRQ-19
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/50-1/200
  Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended.
  Use Polymer anti Mouse/Rabbit IgG as a detection system.
  Positive Control: Pancreatic ductal carcinoma.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: M1 Mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(ab-) patient.
• Specificity: Recognizes Mucin-5AC
  Cellular Localization: Cell membrane.
• Formulation: State: Supernatant
  State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
• Storage: Store the antibody undiluted at 2-8°C.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens microphthalmia-associated transcription factor (MITF), transcript variant 4
• Database Link:
  Entrez Gene 4286 HumanEntrez Gene 4586 Human
• Background: Mucins are high molecular eight glycoproteins with 80% carbohydrate contents and the remaining 20% is constituted by protein core. Gastric mucin M1 antigens are detected/found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in those of normal colon. Evidence from the literature suggestes that they are associated with the peptide core of mucins Resurgence of gastric Mucin reactivity during colonic carcinogenesis is suggested to be due to either reexpression of the peptide core of gastric (or fetal colonic) mucins in the adult colon or due to changes in the glycosylation pattern of mucin which expose the hidden M1 antigens.
• Synonyms: MUC5AC, MUC5, TBM, LeB

Reference Data

• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Melanogenesis, Melanoma, Pathways in cancer