CD11a / ITGAL Rat Monoclonal Antibody [Clone ID: M17/4]

CAT#: AM12064LE-N

CD11a / ITGAL rat monoclonal antibody, clone M17/4, Low Endotoxin


USD 210.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name M17/4
Applications FC, FN, IHC, IP
Recommended Dilution Flow Cytometry: 1 μg/ml.
Immunoprecipitation.
Immunohistochemistry on frozen sections (acetone fixation).
Positive control: mouse spleen or thymus.
Functional Application: Blocking.
Reactivities Mouse
Host Rat
Isotype IgG2a
Clonality Monoclonal
Immunogen C57BL/6 mouse splenic secondary cytotoxic T lymphocytes
Specificity The antibody reacts with CD11a (alpha-subunit of murine LFA-1), a 180 kDa type I transmembrane glycoprotein expressed on B and T lymphocytes, monocytes, macrophages, neutrophils, basophils and eosinophils.
Formulation Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. Endotoxin level is less than 0.1 EU/μg of the protein, as determined by the LAL test.
State: Low Endotoxin
State: Liquid Ig fraction
Concentration 1.0 mg/ml
Purification Protein-G affinity chromatography
Background CD11a (LFA-1 alpha) together with CD18 constitute leukocyte function-associated antigen 1 (LFA-1), the alphaLbeta2 integrin. CD11a is implicated in activation of LFA-1 complex. LFA-1 is expressed on the plasma membrane of leukocytes in a low-affinity conformation. Cell stimulation by chemokines or other signals leads to induction the high-affinity conformation, which supports tight binding of LFA-1 to its ligands, the intercellular adhesion molecules ICAM-1, -2, -3. LFA-1 is thus involved in interaction of various immune cells and in their tissue-specific settlement, but participates also in control of cell differentiation and proliferation and of T-cell effector functions.
Synonyms Integrin alpha-L, LFA1, LFA-1
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.