Caspase-7 (CASP7) Mouse Monoclonal Antibody [Clone ID: 10-1-62]

CAT#: AM20348PU-N

Caspase-7 (CASP7) mouse monoclonal antibody, clone 10-1-62, Purified

Product Images

AM20348PU-N Caspase-7 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Colon followed by biotinylated anti-Mouse IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen.

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  AM20348PU-N Caspase-7 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Spleen followed by biotinylated anti-Mouse IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen.

Specifications

Product Data

• Clone Name: 10-1-62
• Applications: IHC, WB
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 10 µg/ml.
  Western Blot: 1 µg/ml.
• Reactivities: Hamster, Human, Monkey, Mouse, Rat
• Host: Mouse
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: Recombinant Human Caspase-7 full length protein.
• Specificity: Detects an ~37 kD protein, corresponding to the apparent molecular mass of the Caspase-7 on SDS-PAGE immunoblots, in samples from Human, Mouse, Rat, Monkey and Hamster origins. This antibody recognizes recombinant Caspase-7 as well as full length pro-caspase-7 and processed enzyme from apoptotic Jurkat cell lysates.
• Formulation: 10mM Sodium Phosphate, pH 7.2, 50mM Sodium Chloride with 0.1 mM PMSF
  State: Purified
  State: Liquid purified Ig fraction
• Purification: Protein G Chromatography
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens caspase 7 (CASP7), transcript variant a
• Database Link:
  Entrez Gene 12369 MouseEntrez Gene 64026 RatEntrez Gene 697633 MonkeyEntrez Gene 840 Human
• Background: Caspases are cysteine proteases, expressed as inactive precursors, that mediate apoptosis by proteolysis of specific substrates. Caspases have the ability to cleave after aspartic acid residues. There are two classes of caspases involved in apoptosis; initiators (activation by receptor cluster) and effectors (activation by mitochondrial permeability transition). Proapoptotic signals autocatalytically activate initiator caspases, such as Caspase 8 and Caspase 9. Activated initiator caspases then process effector caspases, such as Caspase 3 and Caspase 7, which in turn cause cell collapse.
• Synonyms: CASP-7, CASP7, MCH3, CMH-1

Reference Data

• Protein Families: Druggable Genome, Protease
• Protein Pathways: Alzheimer's disease, Apoptosis