CD34 Mouse Monoclonal Antibody [Clone ID: n.a]

CAT#: AM20524FC-N

CD34 mouse monoclonal antibody, clone n.a, FITC

Product Images

AM20524FC-N CD34 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Lung at 1/50 followed by biotinylated anti-Mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

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  AM20524FC-N CD34 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Placenta at 1/50 followed by biotinylated anti-Mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Specifications

Product Data

• Clone Name: n.a
• Applications: FC, IHC
• Recommended Dilution: Flow Cytometry.
  Immunohistochemistry on Frozen Sections.
  Immunohistochemistry on Paraffin Sections: 1/50.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: CD34
• Specificity: Recognizes Human CD34 Class III epitope which is resistant to Neuraminidase, Chymopapain and Glycoprotease.
• Formulation: PBS containing 0.09% Sodium Azide as preservative and a stabilizing agent
  Label: FITC
  State: Liquid purified IgG fraction
  Label: Fluorescein
• Concentration: lot specific
• Conjugation: FITC
• Storage: Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
  This product is photosensitive and should be protected from light.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Gene Name: Homo sapiens CD34 molecule (CD34), transcript variant 1
• Database Link:
  Entrez Gene 947 Human
• Background: The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.
• Synonyms: Hematopoietic progenitor cell marker

Reference Data

• Protein Families: Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs), Hematopoietic cell lineage