CD19 Mouse Monoclonal Antibody [Clone ID: 4G7]

CAT#: AM26006BT-N

CD19 mouse monoclonal antibody, clone 4G7, Biotin

Product Images

Surface staining of human peripheral blood leukocytes with anti-human CD19 (4G7) purified.

Specifications

Product Data

• Clone Name: 4G7
• Applications: FC
• Recommended Dilution: Indirect immunofluorescence analysis by Flow Cytometry.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human CCL (chronic lymphocytic leukemia) cells
• Specificity: The mouse monoclonal antibody 4G7 recognizes CD19 (B4), a 95 kDa type I transmembrane glycoprotein of immunoglobulin superfamily, expressed on B lymphocytes and follicular dendritic cells; it is lost on plasma cells.
• Formulation: PBS
  Label: Biotin
  State: Liquid purified Ig fraction
  Preservative: 15 mM sodium azide
  Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
• Concentration: lot specific
• Conjugation: Biotin
• Storage: Store at 2-8°C. Do not freeze.
• Stability: Shelf life: One year from despatch.
• Database Link:
  Entrez Gene 930 Human
• Background: CD19 is a transmembrane glycoprotein of Ig superfamily expressed by B cells from the time of heavy chain rearrangement until plasma cell differentiation. It forms a tetrameric complex with CD21 (complement receptor type 2), CD81 (TAPA-1) and Leu13. Together with BCR (B cell antigen receptor), this complex signals to decrease B cell treshold for activation by the antigen. Besides being signal-amplifying coreceptor for BCR, CD19 can also signal independently of BCR coligation and it turns out to be a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
• Synonyms: Leu-12, B-cell marker