CD45 / LCA Rat Monoclonal Antibody [Clone ID: EM-05]

CAT#: AM26024PU-N

CD45 / LCA rat monoclonal antibody, clone EM-05, Purified


USD 165.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name EM-05
Applications FC, IF, IP, WB
Recommended Dilution Flow cytometry: 2 μg/ml.
Positive control: murine peripheral blood leukocytes.
Immunoprecipitation.
Western blot.
Immunocytochemistry.
Reactivities Mouse
Host Rat
Isotype IgG
Clonality Monoclonal
Immunogen Murine peripheral blood leukocytes
Specificity This antibody reacts with mouse CD45 antigen (Leukocyte Common Antigen), a single chain type I transmembrane protein expressed at high level on cells of hematopoietic origin, except erythrocytes and platelets.
Formulation Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
State: Purified
State: Liquid Ig fraction
Concentration 1.0 mg/ml
Purification Purified by protein A (> 95% pure by SDS-PAGE)
Background CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Synonyms PTPRC, Leukocyte common antigen, L-CA, T200
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.