HSP90AA1 Mouse Monoclonal Antibody [Clone ID: MBH90AB]
Other products for "HSP90AA1"
Specifications
Product Data | |
Clone Name | MBH90AB |
Applications | IP, WB |
Recommended Dilution | Western blot: 1 μg/ml. Does not work reliable in Immunoprecipitation. |
Reactivities | Bovine, Human, Mouse |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Peptide within N-terminal part of human Hsp90 |
Specificity | This antibody recognizes the epitope EEEVE within N-terminal part of ubiquitously expressed Hsp90 alpha and Hsp90 beta proteins with calculated Mw of 84.7 kDa and 83.3 kDa, respectively, however, migrating as 90 kDa bands under reducing SDS-PAGE conditions. |
Formulation | Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent State: Aff - Purified State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein-A affinity chromatography (> 95% pure by SDS-PAGE) |
Storage | Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens heat shock protein 90kDa alpha family class A member 1 (HSP90AA1), transcript variant 2 |
Database Link | |
Background | Hsp90 (heat shock protein 90) is one of the most abundant chaperones in the cytosol of eukaryotic cells. It interacts with various proteins, including protein kinases and transcription factors, and either facilitates their stabilization and activation or directs them for proteasomal degradation. Hsp90 thus affects multiple signaling pathways and biological processes and modulation of this single target offers the prospect of simultaneous intervence to various key points of oncogenic transformation. Hsp90 operates as a dimer in a conformational cycle driven by ATP binding and hydrolysis. There are two isoforms, alpha and beta, of vertebrate Hsp90. Whereas Hsp90 beta is expressed constitutively to a high level, Hsp90 alpha is stress-inducible and is overexpressed in many cancerous cells. |
Synonyms | HSP90AB1, HSP90B, HSPC2, HSPCB, HSP84, HSP-90, HSP-84, Heat shock protein HSP 90-beta, HSP84, HSP-84, HSP90AA1, HSP90A, HSPC1, HSPCA, HSP86, HSP-86, Renal carcinoma antigen NY-REN-38, Heat shock protein HSP 90-alpha, HSP86, HSP-86 |
Reference Data | |
Protein Families | Druggable Genome |
Protein Pathways | Antigen processing and presentation, NOD-like receptor signaling pathway, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer |
Documents
Product Manuals |
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