Integrin alpha E (ITGAE) Mouse Monoclonal Antibody [Clone ID: Ber-ACT8]
CAT#: AM26142FC-N
Integrin alpha E (ITGAE) mouse monoclonal antibody, clone Ber-ACT8, FITC
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Specifications
Product Data | |
Clone Name | Ber-ACT8 |
Applications | FC |
Recommended Dilution | Flow Cytometry analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 10e6 cells in a suspension. |
Reactivities | Human, Primate |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | HTLV-1 induced human T cell line MAPS16 |
Specificity | This antibody detects CD103 (alpha E integrin), a type I transmembrane glycoprotein primarily found on intestinal intraepithelial lymphocytes. |
Formulation | Phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent Label: FITC State: Liquid purified Ig fraction Label: Conjugated with Fluorescein isothiocyanate under optimum conditions |
Conjugation | FITC |
Storage | Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light. |
Stability | Shelf life: one year from despatch. |
Gene Name | Homo sapiens integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) (ITGAE) |
Database Link | |
Background | CD103 / Integrin alphaE is an integrin subunit that is expressed on intraepithelial lymphocytes, epithelial dendritic cells, lamina propria-derived dendritic cells, a subpopulation of lamina propria T cells, a small subset of peripheral lymphocytes, namely T reg cells, and on activated and TGF-beta stimulated lymphocytes. CD103 is in mature form cleaved into two disulfide-linked chains (C-terminal 150 kDa chain and N-terminal 25 kDa chain). It heterodimerizes with integrin beta7 subunit to form alphaE/beta7 integrin (mucosal lymphocyte 1 antigen), which through binding E-cadherin mediates homing of lymphocytes to the intestinal epithelium, and, in addition to the role in adhesion, may serve as an accessory molecule for intraepithelial lymphocyte activation. |
Synonyms | Integrin alpha-E, Integrin alpha-IEL, HML-1 antigen, ITGAE |
Reference Data | |
Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
Protein Pathways | Regulation of actin cytoskeleton |
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