MRP8 (S100A8) Mouse Monoclonal Antibody [Clone ID: 7C12/4]

CAT#: AM26218PU-N

MRP8 (S100A8) mouse monoclonal antibody, clone 7C12/4, Purified

Specifications

Product Data

• Clone Name: 7C12/4
• Applications: ELISA, WB
• Recommended Dilution: Flow cytometry: The typical starting working dilution is 1:10.
  Immunoassay (as detector).
  Western blot: The typical starting working dilution is 1:10.
• Reactivities: Human
• Host: Mouse
• Isotype: IgM
• Clonality: Monoclonal
• Specificity: This antibody recognizes an epitope on the S100A8 (MRP-8) protein.
• Formulation: PBS
  State: Purified
  State: LIquid 0.2 µm filtered Ig fraction
  Stabilizer: 0.1% bovine serum albumin
  Preservative: 0.02% sodium azide
• Concentration: lot specific
• Purification: Protein G
• Storage:

  Store at 2 - 8 °C.
  

• Stability: Shelf life: one year from despatch.

• Database Link:
  Entrez Gene 6279 Human
• Background: The calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9) belong to the S100 protein family. The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is a calcium-dependent process. The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. In inflammatory conditions small venueles stain with both anti-S100A8 and S100A9. The staining of the two subunits is always coincident. The S100A8/A9 complex has antibacterial, antifungal and immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils.
• Synonyms: S100-A8, CAGA, MRP-8, CFAG