IL1 Receptor II (IL1R2) Mouse Monoclonal Antibody [Clone ID: 6G5]
CAT#: AM26270PU-N
IL1 Receptor II (IL1R2) mouse monoclonal antibody, clone 6G5, Purified
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Specifications
Product Data | |
Clone Name | 6G5 |
Applications | ELISA |
Recommended Dilution | Immunoassay. |
Reactivities | Human |
Host | Mouse |
Isotype | IgG2a |
Clonality | Monoclonal |
Specificity | The antibody reacts specificly with IL-1RII. |
Formulation | PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide |
Concentration | 0.1 mg/ml |
Purification | Protein G |
Gene Name | interleukin 1 receptor type 2 |
Database Link | |
Background | The IL-1 system includes two agonists (IL-1alpha and IL-1beta), converting enzymes, antagonists, two receptors (IL-1RI and IL-1RII) and the IL-1 receptor accessory protein. The IL-1RII is part of the antagonistic IL-1 mechanism. It is also known as decoy receptor and is a non signaling molecule which functions by capturing IL-1 and preventing it from interacting with the signalling IL-1RI. The decoy IL-1RII can after binding to IL-1 also recruit the IL-1 receptor accessory protein and thus inhibit by coreceptor competition. Further a soluble form of IL-1RII exists which is shed, a process in which matrix metalloproteases have been found to play a role, by various cells including monocytes, polymorphonuclear cells, B cells and fibroblasts |
Synonyms | Interleukin-1 receptor type II, IL-1R-2, IL-1R-beta, CDw121b, IL1RB |
Reference Data |
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