Vcam1 Rat Monoclonal Antibody [Clone ID: 6C7.1]

CAT#: AM26309PU-N

Vcam1 rat monoclonal antibody, clone 6C7.1, Purified


USD 330.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 6C7.1
Applications FC, FN, IF, IHC, IP
Recommended Dilution Immunohistochemistry on frozen sections.
Flow cytometry: The typical starting working dilution is 1:50.
Functional assays.
Immunoflourescence: The typical starting working dilution is 1:50.
Immunoprecipitation.
Reactivities Mouse
Host Rat
Isotype IgG1
Clonality Monoclonal
Immunogen Mouse endothelial cells
Specificity The monoclonal antibody 6C7.1 recognizes mouse vascular cell adhesion molecule (VCAM-1).
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Concentration 0.1 mg/ml
Purification Protein G
Background VCAM-1 (~ 81 kDa) is a member of a subclass of the immunoglobulin superfamily (IgSF). IgSF members are ligands for integrins. Cell adhesion molecules (CAMs) have important roles in the immune response, immune surveillance and cell-cell recognition, especially in leukocyte-endothelial cell adhesion. CAMs on the surface of leukocytes and endothelial cells are actively involved in the recruitment of specific leukocyte subsets into different tissues. VCAM-1 is expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Cell adhesion molecules, like VCAM-1, are upregulated on cerebral vessels during inflammatory conditions of the central nervous system such as experimental autoimmune encephalomyelitis (EAE), a model system for multiple sclerosis. Administration of monoclonal antibody 6C7.1 has been shown to inhibit or diminish clinical or pathological signs of EAE. VCAM-1 is a receptor for encephalomyocarditis virus on murine vascular endothelial cells. Expression of VCAM-1 on vascular endothelial cells is induced by TNF-alpha, IL-1, IFN-gamma or endotoxin. VCAM-1 is a ligand for the integrins alpha4beta1 (VLA-4) and alpha4beta7 (LPAM-1). These integrins are constitutively expressed by thymocytes, lymphocytes and monocytes. VCAM-1/VLA-4 interaction may play a pathophysiological role in immune responses and as well as in leukocyte emigration to sites of inflammation.
Synonyms V-CAM 1, INCAM-100, L1CAM, VCAM-1
Reference Data

{0} Product Review(s)

0 Product Review(s) Submit review

Be the first one to submit a review

Product Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.