Mpo Mouse Monoclonal Antibody [Clone ID: 8F4]
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Specifications
Product Data | |
Clone Name | 8F4 |
Applications | ELISA, IHC |
Recommended Dilution | Immunohistochemistry on frozen sections (3,4): The typical starting working dilution is 1:50. Flow cytometry (2,5): The typical starting working dilution is 1:50. Immunoassays (1,3). Positive control: Neutrophils isolated from digested infarcts. Negative control: Lymphocytes isolated from digested infarcts. Does not work in Immunohistochemistry on paraffin sections. |
Reactivities | Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Purified mouse MPO from WEHI-3 cells |
Specificity | The monoclonal antibody 8F4 recognizes mouse myeloperoxidase (MPO). |
Formulation | PBS Label: Biotin State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide |
Concentration | 0.1 mg/ml |
Purification | Protein G |
Conjugation | Biotin |
Gene Name | myeloperoxidase |
Database Link | |
Background | MPO is a glycoprotein produced as a single precursor, which is subsequently cleaved into a alpha and beta chain. In human the biologically active MPO is a 150kDa tetramer composed of 2 glycosylated alfa chains of 59-64 kDa and 2 beta chains of 14 kDa. MPO is stored in azurophilic granules of polymorphonuclear leukocytes and is rapidly released into the phagosome and extracellular space during inflammatory conditions.The enzyme catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, a potent oxidant, which functions in host defense against microorganisms. |
Synonyms | MPO |
Reference Data |
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