Complement C3 (C3) (neoantigen) Rat Monoclonal Antibody [Clone ID: 9]

CAT#: AM26358PU-N

Complement C3 (C3) (neoantigen) rat monoclonal antibody, clone 9, Purified


USD 465.00

2 Weeks*

Size
    • 100 ug

Product Images

Specifications

Product Data
Clone Name 9
Applications ELISA, IP
Recommended Dilution Immunoassays.
Immunoprecipitation.
Reactivities Human
Host Rat
Isotype IgG1
Clonality Monoclonal
Specificity The monocolonal antibody 9 reacts with a neoantigen on iC3, iC3b, C3dg and C3g. It recognizes iC3b, C3dg and C3g in plasma. The antibody does not recognize C3 or C3b.
Formulation PBS
State: Purified
State: Liquid 0.2 µm filtered Ig fraction
Stabilizer: 0.1% bovine serum albumin
Preservative: 0.02% sodium azide
Concentration lot specific
Purification Protein G
Storage

Store at 2 - 8 °C.

Stability Shelf life: one year from despatch.

Gene Name complement component 3
Background

C3g itself however is a small fragment probably not formed in vivo. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components.
The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported.
Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. C3dg can be cleaved into C3d and C3g though this does not occur in plasma.

Synonyms Complement C3
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.