CX3CR1 Mouse Monoclonal Antibody [Clone ID: 1G4]

CAT#: AM26731PU-N

CX3CR1 mouse monoclonal antibody, clone 1G4, Purified

Product Images

Human small intestine, stained with (Paraffin section).

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  Human small intestine, stained with (Paraffin section).

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  Human brain cortex, stained with (Paraffin section).

Specifications

Product Data

• Clone Name: 1G4
• Applications: IHC
• Recommended Dilution: Immunohistochemistry on Paraffin Sections: 2 µg/ml (1/100), pretreatment with proteinase K required.
  Suggested Positive Control: Human brain cortex.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG2b
• Clonality: Monoclonal
• Immunogen: DNA vaccine
• Specificity: This antibody detetcs CX3C Receptor 1.
  The specificity of the antibody was verified by flow cytometry with cells expressing the recombinant protein. The epitope has not been further characterized.
• Formulation: Phosphate buffered saline pH 7.2 (PBS)
  State: Purified
  State: Lyophilized purified IgG fraction from Serum-Free Cell Culture Supernatant
  Stabilizer: 5 mg/ml BSA
  Preservative: 0.1% Kathon
• Reconstitution Method: Restore by adding 0.5 ml distilled water.
• Concentration: 0.2 mg/ml (after reconstitution)
• Purification: Affinity Chromatography on Protein G
• Storage: Store lyophilized at 2-8°C for 6 months or at -20°C long term.
  After reconstitution store the antibody undiluted at 2-8°C for one month
  or (in aliquots) at -20°C long term.
  Avoid repeated freezing and thawing.
• Stability: Shelf life: one year from despatch.
• Database Link:
  Entrez Gene 1524 Human
• Background: G-protein coupled receptor 1 3 (GPR13) is a 355 amino acid protein that belongs to the G - protein coupled receptor 1 family. Biologically, the fractalkine (CX3CL1) to fractalkine receptor (CX3CR1) interactions play an important role in macrophage recruitment to target organs such as the brain, the intestine, the liver or the lungs. Accordingly, expression of the CX3CR1 has been described in inflammation - and tumor - associated macrophages, intestinal lamina propia macrophages, and B cells. Also, CX3CR1 mediates adhesive and migratory functions and acts as a coreceptor with CD4 for HIV - 1 virus gp160 envelope protein.
• Synonyms: CX3C chemokine receptor 1, C-X3-C CKR-1,CMKBRL1, CMK-BRL-1